製品の概要

  • 製品名
    Anti-PARK7/DJ1 antibody, prediluted
    PARK7/DJ1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PARK7/DJ1, prediluted
  • 由来種
    Rabbit
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide from the C-terminal of human DJ1

  • ポジティブ・コントロール
    • Human normal breast tissue.

アプリケーション

Our Abpromise guarantee covers the use of ab74317 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P
  • 追加情報
    IHC-P: Ready-to-use for 30 min at RT. Perform heat mediated antigen retrieval before commencing with IHC staining protocol, by boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min, followed by cooling at RT for 20 min.
  • ターゲット情報

    • 機能
      Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone.
    • 組織特異性
      Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at slightly lower levels in placenta and brain. Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa.
    • 関連疾患
      Defects in PARK7 are the cause of Parkinson disease type 7 (PARK7) [MIM:606324]. A neurodegenerative disorder characterized by resting tremor, postural tremor, bradykinesia, muscular rigidity, anxiety and psychotic episodes. PARK7 has onset before 40 years, slow progression and initial good response to levodopa. Some patients may show traits reminiscent of amyotrophic lateral sclerosis-parkinsonism/dementia complex (Guam disease).
    • 配列類似性
      Belongs to the peptidase C56 family.
    • 翻訳後修飾
      Sumoylated on Lys-130 by PIAS2 or PIAS4; which is enhanced after ultraviolet irradiation and essential for cell-growth promoting activity and transforming activity.
      Cys-106 is easily oxidized to sulfinic acid.
      Undergoes cleavage of a C-terminal peptide and subsequent activation of protease activity in response to oxidative stress.
    • 細胞内局在
      Cytoplasm. Nucleus. Mitochondrion. Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage. Detected in tau inclusions in brains from neurodegenerative disease patients.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CAP1 antibody
      • DJ-1 antibody
      • DJ1 antibody
      • DJ1 protein antibody
      • Epididymis secretory sperm binding protein Li 67p antibody
      • FLJ27376 antibody
      • FLJ34360 antibody
      • FLJ92274 antibody
      • HEL S 67p antibody
      • Oncogene DJ1 antibody
      • OTTHUMP00000001348 antibody
      • OTTHUMP00000001349 antibody
      • OTTHUMP00000001350 antibody
      • OTTHUMP00000001351 antibody
      • PARK7 antibody
      • PARK7_HUMAN antibody
      • Parkinson disease (autosomal recessive, early onset) 7 antibody
      • Parkinson disease protein 7 antibody
      • Parkinson protein 7 antibody
      • Protein DJ-1 antibody
      • SP22 antibody
      see all

    画像

    • Staining of formalin-fixed, paraffin-embedded tissue human breast tissue with ab74317.

    参考文献

    ab74317 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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