製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to PAR6
  • アプリケーション
    適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    A peptide from the n-terminal and a peptide from the c-terminal region of PAR6 conjugated to KLH and co-immunized into rabbits

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 37 kDa.
ICC/IF 1/100.

ターゲット情報

  • 機能
    Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
  • 組織特異性
    Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.
  • 配列類似性
    Belongs to the PAR6 family.
    Contains 1 OPR domain.
    Contains 1 PDZ (DHR) domain.
    Contains 1 pseudo-CRIB domain.
  • ドメイン
    The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
    The OPR domain mediates interactions with MAP2K5.
    The PDZ domain mediates the interaction with CRB3.
  • 細胞内局在
    Cytoplasm. Cell membrane. Cell projection > ruffle. Cell junction > tight junction. Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 0710008C04Rik antibody
    • 2610010A15Rik antibody
    • Par 6 partitioning defective 6 C elegans homolog alpha antibody
    • Par 6 partitioning defective 6 homolog alpha antibody
    • Par 6 partitioning defective 6 homolog alpha C elegans antibody
    • PAR 6A antibody
    • PAR-6 alpha antibody
    • PAR-6 antibody
    • par-6 family cell polarity regulator alpha antibody
    • PAR-6A antibody
    • PAR6 antibody
    • PAR6A_HUMAN antibody
    • PAR6alpha antibody
    • PAR6C antibody
    • Pard6a antibody
    • Partitioning defective 6 homolog alpha antibody
    • partitioning-defective protein 6 antibody
    • partitioning-defective protein 6, C. elegans, homolog of, alpha antibody
    • Tax interacting protein 40 antibody
    • Tax interaction protein 40 antibody
    • TAX40 antibody
    • TIP 40 antibody
    • TIP-40 antibody
    • TIP40 antibody
    see all

参考文献

ab111823 has not yet been referenced specifically in any publications.

レビューと Q&A

Abcam has not validated the combination of species/application used in this Abreview.
Application
Immunohistochemistry (Frozen sections)
Sample
Xenopus laevis Tissue sections (Embryo stage 26)
Permeabilization
No
Specification
Embryo stage 26
Blocking step
Blocking reagent Perkin elmer as blocking agent for 30 minute(s) · Concentration: 1.5% · Temperature: 20°C
Fixative
Paraformaldehyde
Username

Dr. Gerhard Schlosser

Verified customer

投稿 Mar 01 2016

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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