Anti-PAR6 抗体 (ab111823)

製品の概要

• 製品名
  Anti-PAR6 antibody
  PAR6 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to PAR6
• アプリケーション
  適用あり: WB, ICC/IFmore details
• 種交差性
  交差種: Human
  
• 免疫原

  A peptide from the n-terminal and a peptide from the c-terminal region of PAR6 conjugated to KLH and co-immunized into rabbits

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  Preservative: 0.05% Sodium azide
  Constituent: 99.95% Whole serum
• 精製度
  Whole antiserum
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • Cell cycle
  • Cell Differentiation

  • Signal Transduction
  • Cytoskeleton / ECM
  • Cell Adhesion
  • Tight Junctions

  • Cell Biology
  • Cell Cycle
  • Cell Division
  • Other cell division antibodies

  • Cancer
  • Cell cycle
  • Cell division

  • Stem Cells
  • Cancer Stem Cells
  • Intracellular

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能
  Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
• 組織特異性
  Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta.
• 配列類似性
  Belongs to the PAR6 family.
  Contains 1 OPR domain.
  Contains 1 PDZ (DHR) domain.
  Contains 1 pseudo-CRIB domain.
• ドメイン
  The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
  The OPR domain mediates interactions with MAP2K5.
  The PDZ domain mediates the interaction with CRB3.
• 細胞内局在
  Cytoplasm. Cell membrane. Cell projection > ruffle. Cell junction > tight junction. Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions.

• Target information above from: UniProt accession Q9NPB6 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 50855 Human
  • Omim: 607484 Human
  • SwissProt: Q9NPB6 Human
  • Unigene: 112933 Human
• 別名
  • 0710008C04Rik antibody
  • 2610010A15Rik antibody
  • Par 6 partitioning defective 6 C elegans homolog alpha antibody

  • Par 6 partitioning defective 6 homolog alpha antibody
  • Par 6 partitioning defective 6 homolog alpha C elegans antibody
  • PAR 6A antibody
  • PAR-6 alpha antibody
  • PAR-6 antibody
  • par-6 family cell polarity regulator alpha antibody
  • PAR-6A antibody
  • PAR6 antibody
  • PAR6A_HUMAN antibody
  • PAR6alpha antibody
  • PAR6C antibody
  • Pard6a antibody
  • Partitioning defective 6 homolog alpha antibody
  • partitioning-defective protein 6 antibody
  • partitioning-defective protein 6, C. elegans, homolog of, alpha antibody
  • Tax interacting protein 40 antibody
  • Tax interaction protein 40 antibody
  • TAX40 antibody
  • TIP 40 antibody
  • TIP-40 antibody
  • TIP40 antibody

  see all

プロトコール

• Western blot protocols
• Immunocytochemistry & immunofluorescence protocols