製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to PAR4
  • 由来種
    Rabbit
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide from the C-terminus of human PAR4.

  • ポジティブ・コントロール
    • Human heart myocardium and Alzheimer’s brain.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab75686 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC-P
  • 追加情報
    IHC-P: 1/100 for 10 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 37 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
    • 組織特異性
      Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers.
    • ドメイン
      The leucine-zipper domain is not essential for apoptosis, but is required for sensitization of cells to exogenous apoptotic insults and for interaction with its partners.
      The SAC domain is a death-inducing domain selective for apoptosis induction in cancer cells. This domain is essential for nuclear entry, Fas activation, inhibition of NF-kappa-B activity and induction of apoptosis in cancer cells.
    • 翻訳後修飾
      Preferentially phosphorylated at the Thr-163 by PKC in cancer cells.
    • 細胞内局在
      Cytoplasm. Nucleus. Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 2310001G03Rik antibody
      • PAR 4 antibody
      • PAR-4 antibody
      • Pawr antibody
      • PAWR_HUMAN antibody
      • PRKC Apoptosis WT1 Regulator antibody
      • PRKC apoptosis WT1 regulator protein antibody
      • Prostate apoptosis response 4 protein antibody
      • Prostate apoptosis response protein 4 antibody
      • prostate apoptosis response protein PAR-4 antibody
      • Transcriptional repressor Par-4-like protein PAWR antibody
      • Transcriptional repressor PAR4 antibody
      • WT1 Interacting Protein antibody
      see all

    画像

    • ab75686, at 1/100 dilution, staining PAR4 in Human heart by immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

    参考文献

    ab75686 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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