製品の概要

  • 製品名Anti-PAPP A antibody [10H9] (HRP)
    PAPP A 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [10H9] to PAPP A (HRP)
  • 標識HRP
  • アプリケーション適用あり: ELISA, Sandwich ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Purified human PAPPA antigen

  • 特記事項Concentration varies from lot to lot and can be provided on request.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C.
  • バッファーPreservative: 0.05% Proclin
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 精製度Protein A purified
  • 特記事項(精製)Purified by chromatography on protein A. Purity tested by electrophoresis.
  • ポリ/モノモノクローナル
  • クローン名10H9
  • ミエローマSp2/0
  • アイソタイプIgG2a
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab10195 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent dilution. Can be paired for ELISA with Mouse monoclonal [4G11] to PAPP A (ab10192).
Sandwich ELISA Use at an assay dependent dilution. Can be paired for Sandwich ELISA with Mouse monoclonal [4G11] to PAPP A (ab10192). Recommended for the detection of htPAPP-A antigen in pregnancy serum and the detection of dPAPP-A antigen in blood of patients with unstable angina. Can be used as detection antibody in conjunction with ab10192.

ターゲット情報

  • 機能Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
  • 組織特異性High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.
  • 配列類似性Belongs to the peptidase M43B family.
    Contains 5 Sushi (CCP/SCR) domains.
  • 発生段階Present in serum and placenta during pregnancy; levels increase throughout pregnancy.
  • 翻訳後修飾There appear to be no free sulfhydryl groups.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ASBABP2 antibody
    • Aspecific BCL2 ARE binding protein 2 antibody
    • Differentially placenta 1 expressed protein antibody
    • DIPLA1 antibody
    • EC 3.4.24.79 antibody
    • IGF dependent IGFBP 4 protease antibody
    • IGF-dependent IGFBP-4 protease antibody
    • IGFBP 4ase antibody
    • IGFBP-4ase antibody
    • IGFBP4ase antibody
    • Insulin like growth factor dependent IGF binding protein 4 protease antibody
    • Insulin-like growth factor-dependent IGF-binding protein 4 protease antibody
    • PAPA antibody
    • PAPP A antibody
    • PAPP-A antibody
    • PAPP1_HUMAN antibody
    • PAPPA antibody
    • PAPPA1 antibody
    • Pappalysin 1 precursor antibody
    • Pappalysin-1 antibody
    • Pregnancy Associated Plasma Protein A antibody
    • Pregnancy associated plasma protein A pappalysin 1 antibody
    • Pregnancy-associated plasma protein A antibody
    see all

Anti-PAPP A antibody [10H9] (HRP) 画像

  • PAPP A calibration curve for two assays Capture: biotinylated ab10192; 200 ng/well Detection: Eu-labeled ab10194; 400 ng/well (light blue); Eu-labeled 10195, 200 ng/well (dark blue). Strep avidin coated plates. Assay time: 30 min, room temperature.

Anti-PAPP A antibody [10H9] (HRP) (ab10195) 使用論文

ab10195 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"