製品の概要

  • 製品名Anti-PAPP A antibody [004-09]
    PAPP A 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [004-09] to PAPP A
  • 特異性This antibody is specific for native human PAPP A. Heat and SDS denatured PAPP A is also recognized, but not acid treated PAPP A.
  • アプリケーション適用あり: WB, ELISA, IHC-P, IHC-Frmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length native protein (purified) (Human)

  • エピトープThe epitope is located on the PAPP A subunit of the heterotetramer.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 15mM Sodium Azide
    Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4
  • Concentration information loading...
  • 特記事項(精製)Protein A/G purified
  • ポリ/モノモノクローナル
  • クローン名004-09
  • アイソタイプIgG2b
  • 軽鎖の種類kappa
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab52030 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 181 kDa.
ELISA 1/8000. This antibody can also be used as detection antibody in sandwich ELISA in combination with a polyclonal antibody towards PAPP A in coat.
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

ターゲット情報

  • 機能Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
  • 組織特異性High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.
  • 配列類似性Belongs to the peptidase M43B family.
    Contains 5 Sushi (CCP/SCR) domains.
  • 発生段階Present in serum and placenta during pregnancy; levels increase throughout pregnancy.
  • 翻訳後修飾There appear to be no free sulfhydryl groups.
  • 細胞内局在Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ASBABP2 antibody
    • Aspecific BCL2 ARE binding protein 2 antibody
    • Differentially placenta 1 expressed protein antibody
    • DIPLA1 antibody
    • EC 3.4.24.79 antibody
    • IGF dependent IGFBP 4 protease antibody
    • IGF-dependent IGFBP-4 protease antibody
    • IGFBP 4ase antibody
    • IGFBP-4ase antibody
    • IGFBP4ase antibody
    • Insulin like growth factor dependent IGF binding protein 4 protease antibody
    • Insulin-like growth factor-dependent IGF-binding protein 4 protease antibody
    • PAPA antibody
    • PAPP A antibody
    • PAPP-A antibody
    • PAPP1_HUMAN antibody
    • PAPPA antibody
    • PAPPA1 antibody
    • Pappalysin 1 precursor antibody
    • Pappalysin-1 antibody
    • Pregnancy Associated Plasma Protein A antibody
    • Pregnancy associated plasma protein A pappalysin 1 antibody
    • Pregnancy-associated plasma protein A antibody
    see all

Anti-PAPP A antibody [004-09] 画像

  • Ab52030 staining human PAPP A in human placenta tissue by immunohistochemistry using frozen tissue. Staining (red-brown) is restricted to the syncytiotrophoblast of the chorionic villi.
  • Ab52030 staining human PAPP A in human placenta tissue by immunohistochemistry using parrafin embedded tissue. Staining (red-brown) is restricted to the syncytiotrophoblast of the chorionic villi.

Anti-PAPP A antibody [004-09] (ab52030) 使用論文

This product has been referenced in:
  • Sun Y  et al. MiR-490-3p modulates the proliferation of vascular smooth muscle cells induced by ox-LDL through targeting PAPP-A. Cardiovasc Res 100:272-9 (2013). Read more (PubMed: 23821525) »

See 1 Publication for this product

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Iam sorry to confirm thatwe do not have the requested information.

The immunogen used to raise ab52030 was PAPP-A purified from fluid containing maternal serum aspirated during cesarean section (“cesa...

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ab59086: Five different pappalysin-1 sequences are published thus far; 1628, 1627, 1420, 1232 and 704 amino acids in length. The shorter forms start with the second methionine, 209 residues downstream from the long...

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