Use at an assay dependent concentration. PubMed: 23700402
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation.
Expressed in brain. Within brain, it is expressed in cerebellum, hippocampus and medulla.
Belongs to the DNA polymerase type-B-like family. GLD2 subfamily. Contains 1 PAP-associated domain.
Kinjo ER et al. Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons. Sci Rep6:20969 (2016).
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de Sousa É et al. Developmental and functional expression of miRNA-stability related genes in the nervous system. PLoS One8:e56908 (2013).
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