Anti-pan Synuclein 抗体, prediluted (ab15535)


  • 製品名Anti-pan Synuclein antibody, prediluted
    pan Synuclein 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to pan Synuclein, prediluted
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Rat
  • 免疫原

    Synthetic peptide within Human pan Synuclein (N terminal). The exact sequence is proprietary. A synthetic peptide corresponding to near N-terminal of human alpha, beta, gamma Synuclein protein.

  • ポジティブ・コントロール
    • IHC-P: Human brain tissue.



Our Abpromise guarantee covers the use of ab15535 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Ready-to-use for 10 min at RT. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.


  • 関連性Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors. The family includes three known proteins: alpha, beta and gamma synucleins. Synuclein-alpha is primarily localized at the presynaptic region of axons and it may be involved in the regulation of dopamine release and transport. However, it can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Synuclein-alpha may induce fibrillization of the microtubule-associated protein tau and it reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Synuclein-alpha is involved in Parkinson's disease, Lewy body dementia, Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome) and it is a major non-amyloid component of the deposits associated with Alzheimer's disease. Synuclein-beta may be a regulator of the SNCA aggregation process. It protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation that also involves p53 and contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Gamma synuclein is found primarily in the peripheral nervous system and retina. High levels of expression have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.
  • 細胞内局在Neuronal cytosol and presynaptic terminals
  • 参照データベース
  • 別名
    • BCSG1 antibody
    • beta synuclein antibody
    • Breast cancer specific gene 1 protein antibody
    • Gamma synuclein antibody
    • NACP antibody
    • PARK1 antibody
    • Persyn antibody
    • PRSN antibody
    • SNCA antibody
    • SNCB antibody
    • SNCG antibody
    • SR antibody
    • Synoretin antibody
    see all

Anti-pan Synuclein antibody, prediluted 画像

  • ab15535 staining pan Synuclein in Human brain tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
  • ab15535 staining pan Synuclein in Human brain tissue.

Anti-pan Synuclein antibody, prediluted (ab15535) 使用論文

ab15535 has not yet been referenced specifically in any publications.

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