製品の概要

  • 製品名
    Anti-pan Sodium Channel antibody
  • 製品の詳細
    Rabbit polyclonal to pan Sodium Channel
  • 特異性
    Detects endogenous levels of total sodium channel protein.
  • アプリケーション
    適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to Human pan Sodium Channel.

  • ポジティブ・コントロール
    • Extracts from HuvEc cells.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab53724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/20000.
WB 1/500 - 1/1000. Detects a band of approximately 227 kDa (predicted molecular weight: 227 kDa).

ターゲット情報

  • 関連性
    The pan sodium ion channel, SCN5A, is a cardiac sodium channel distinct from those in nerve and muscle. It is a tetrodotoxin-resistant Na(+) channel isoform. SCN5A mediates the voltage-dependent sodium ion permeability of excitable membranes by opening or closing in response to the voltage difference across the membrane. Na(+) ions pass in accordance with their electrochemical gradient. This channel is responsible for the initial upstroke of the action potential in the electrocardiogram. Defects in SCN5A are involved in many diseases including: progressive familial heart block type I (PFHBI), also known as Lenegre-Lev disease or progressive cardiac conduction defect (PCCD); long QT syndrome type 3 (LQT3); Brugada syndrome; sick sinus syndrome 1 (SSS1); idiopathic ventricular fibrillation (IVF), also called paroxysmal familial ventricular fibrillation; sudden infant death syndrome (SIDS); familial atrial standstill and dilated cardiomyopathy 1E (CMD1E).
  • 細胞内局在
    Cell Membrane; Multi-pass membrane protein.
  • 参照データベース
  • 別名
    • HBSC II antibody
    • HH1 antibody
    • hNaN antibody
    • hNE-Na antibody
    • hPN3 antibody
    • KIAA1356 antibody
    • MED antibody
    • NAC1 antibody
    • NAC2 antibody
    • NAC3 antibody
    • NENA antibody
    • Neuroendocrine sodium channel antibody
    • Peripheral nerve sodium channel 3 antibody
    • Peripheral nerve sodium channel 5 antibody
    • Peripheral sodium channel 1 antibody
    • PN1 antibody
    • PN3 antibody
    • PN5 antibody
    • SCN1 antibody
    • SCN10A antibody
    • SCN11A antibody
    • SCN12A antibody
    • SCN1A antibody
    • SCN2A antibody
    • SCN2A1 antibody
    • SCN2A2 antibody
    • SCN3A antibody
    • SCN4A antibody
    • SCN5A antibody
    • SCN8A antibody
    • SCN9A antibody
    • Sensory neuron sodium channel 2 antibody
    • SkM1 antibody
    • SNS2 antibody
    • Sodium channel protein brain I subunit alpha antibody
    • Sodium channel protein brain II subunit alpha antibody
    • Sodium channel protein brain III subunit alpha antibody
    • Sodium channel protein cardiac muscle subunit alpha antibody
    • Sodium channel protein skeletal muscle subunit alpha antibody
    • Sodium channel protein type 1 subunit alpha antibody
    • Sodium channel protein type 10 subunit alpha antibody
    • Sodium channel protein type 11 subunit alpha antibody
    • Sodium channel protein type 2 subunit alpha antibody
    • Sodium channel protein type 3 subunit alpha antibody
    • Sodium channel protein type 4 subunit alpha antibody
    • Sodium channel protein type 5 subunit alpha antibody
    • Sodium channel protein type 8 subunit alpha antibody
    • Sodium channel protein type 9 subunit alpha antibody
    • Sodium channel protein type II subunit alpha antibody
    • Sodium channel protein type III subunit alpha antibody
    • Sodium channel protein type IV subunit alpha antibody
    • Sodium channel protein type IX subunit alpha antibody
    • Sodium channel protein type V subunit alpha antibody
    • Sodium channel protein type VIII subunit alpha antibody
    • Sodium channel protein type X subunit alpha antibody
    • Sodium channel protein type XI subunit alpha antibody
    • Voltage-gated sodium channel subtype III antibody
    • Voltage-gated sodium channel subunit alpha Nav1.1 antibody
    • Voltage-gated sodium channel subunit alpha Nav1.2 antibody
    • Voltage-gated sodium channel subunit alpha Nav1.3 antibody
    • Voltage-gated sodium channel subunit alpha Nav1.4 antibody
    • Voltage-gated sodium channel subunit alpha Nav1.5 antibody
    • Voltage-gated sodium channel subunit alpha Nav1.6 antibody
    • Voltage-gated sodium channel subunit alpha Nav1.7 antibody
    • Voltage-gated sodium channel subunit alpha Nav1.8 antibody
    • Voltage-gated sodium channel subunit alpha Nav1.9 antibody
    see all

画像

  • All lanes : Anti-pan Sodium Channel antibody (ab53724) at 1/500 dilution

    Lane 1 : extracts from HuvEc cells
    Lane 2 : extracts from HuvEc cells with immunizing peptide


    Predicted band size : 227 kDa
    Observed band size : 227 kDa

プロトコール

参考文献

ab53724 has not yet been referenced specifically in any publications.

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