Anti-pan Cytokeratin 抗体 [C-11] (ab118817)

製品の概要

  • 製品名Anti-pan Cytokeratin antibody [C-11]
    pan Cytokeratin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [C-11] to pan Cytokeratin
  • 特異性Reacts with Cytokeratin peptides 4, 5, 6, 8, 10, 13, 18.
  • アプリケーション適用あり: WB, IP, IHC-P, ICC, Flow Cytmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: all Mammals
  • 免疫原

    Tissue, cells or virus corresponding to Human pan Cytokeratin.

  • ポジティブ・コントロール
    • Human Breast tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab118817 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 60 kDa.
IP Use at an assay dependent concentration.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 関連性Cytokeratins, a group comprising at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratins 1, 4, 5, 6, and 8 are members of the type II neutral to basic subfamily. Monoclonal anti cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. Monoclonal Anti Pan Cytokeratin (mixture) is a broadly reactive reagent, which recognizes epitopes present in most human epithelial tissues. It facilitates typing of normal, metaplastic and neoplastic cells. Synergy between the various components results in staining amplification. This enables identification of cells, which would otherwise be stained only marginally. The mixture may aid in the discrimination of carcinomas and nonepithelial tumors such as sarcomas, lymphomas and neural tumors. It is also useful in detecting micrometastases in lymph nodes, bone marrow and other tissues and for determining the origin of poorly differentiated tumors. There are two types of cytokeratins the acidic type I cytokeratins and the basic or neutral type II cytokeratins. Cytokeratins are usually found in pairs comprising a type I cytokeratin and a type II cytokeratin. Usually the type II cytokeratins are 8kD larger than their type I counterparts.
  • 細胞内局在Cytoplasmic
  • 参照データベース

Anti-pan Cytokeratin antibody [C-11] 画像

  • ab118817, at 10 µg/ml, staining Keratin in formalin-fixed, paraffin-embedded Human Breast tissue by Immunohistochemistry using a biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-pan Cytokeratin antibody [C-11] (ab118817) 使用論文

ab118817 has not yet been referenced specifically in any publications.

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