製品の概要

  • 製品名Anti-PAK1 antibody
    PAK1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to PAK1
  • 特異性Detects endogenous levels of total PAK1.
  • アプリケーション適用あり: WB, IHC-P, ICC/IF, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic non-phosphopeptide derived from Human PAK1 around the phosphorylation site of serine 199 (T-K-S-V-Y)

  • ポジティブ・コントロール
    • K562 cells extracts; Human placenta tissue.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab79218 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 61 kDa.
IHC-P 1/50 - 1/100.
ICC/IF 1/500 - 1/1000.
ELISA 1/10000.

ターゲット情報

  • 機能The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
  • 配列類似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 CRIB domain.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Autophosphorylated when activated by CDC42/p21 and RAC1.
  • 細胞内局在Cytoplasm. Cell junction > focal adhesion. Recruited to focal adhesions upon activation.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ADRB2 antibody
    • Alpha PAK antibody
    • Alpha-PAK antibody
    • MGC130000 antibody
    • MGC130001 antibody
    • p21 activated kinase 1 antibody
    • p21 protein (Cdc42/Rac) activated kinase 1 antibody
    • p21-activated kinase 1 antibody
    • p21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related) antibody
    • p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) antibody
    • p65 PAK antibody
    • p65-PAK antibody
    • P68-PAK antibody
    • PAK alpha antibody
    • PAK-1 antibody
    • Pak1 antibody
    • PAK1_HUMAN antibody
    • Paka antibody
    • PAKalpha antibody
    • Protein kinase MUK2 antibody
    • Rac/p21-activated kinase antibody
    • Serine/threonine-protein kinase PAK 1 antibody
    • STE20 homolog yeast antibody
    see all

Anti-PAK1 antibody 画像

  • Left panel: immunohistochemistry analysis of paraffin-embedded Human placenta tissue using 1/50 ab79218; Right panel: same, after pre-incubation with the immunizing peptide.
  • All lanes : Anti-PAK1 antibody (ab79218) at 1/500 dilution

    Lane 1 : K562 cells extract
    Lane 2 : K562 cells extract with immunizing peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 61 kDa
    Observed band size : 61 kDa

Anti-PAK1 antibody (ab79218) 使用論文

ab79218 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"