製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to PACS1
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to C terminal residues of human PACS1 (Phosphofurin acidic cluster sorting protein 1)

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab56072 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報
    ELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 µg/ml for 2hrs. Predicted molecular weight: 105 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.
    • 関連疾患
      Mental retardation, autosomal dominant 17
    • 配列類似性
      Belongs to the PACS family.
    • 細胞内局在
      Golgi apparatus, trans-Golgi network. Localizes in the perinuclear region, probably the TGN.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Cytosolic sorting protein PACS1 antibody
      • PACS 1 antibody
      • PACS-1 antibody
      • Pacs1 antibody
      • PACS1_HUMAN antibody
      • Phosphofurin acidic cluster sorting protein 1 antibody
      see all

    画像



    • Predicted band size : 105 kDa

      Image from Yi L et al, J Biol Chem. 2010 Oct 1;285(40):30884-905. Epub 2010 Jul 9, Fig 4. DOI 10.1074/jbc.M110.135947

    プロトコール

    参考文献

    This product has been referenced in:
    • Budhiraja S  et al. Mining the human complexome database identifies RBM14 as an XPO1-associated protein involved in HIV-1 Rev function. J Virol 89:3557-67 (2015). Read more (PubMed: 25589658) »
    • Werneburg NW  et al. Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) induced lysosomal translocation of proapoptotic effectors is mediated by phosphofurin acidic cluster sorting protein-2 (PACS-2). J Biol Chem : (2012). WB ; Human . Read more (PubMed: 22645134) »

    See all 3 Publications for this product

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