製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to PABPC4
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus
  • 免疫原

    Synthetic peptide, corresponding to a region within internal sequence amino acids 525-575 of Human PABPC4 (NP_003810.1).

  • ポジティブ・コントロール
    • Human Bladder Cell Carcinoma, Breast Carcinoma, Colon Carcinoma, Ovarian Carcinoma and Prostate Carcinoma. Mouse Teratoma.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab101492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100 - 1/500. Antigen retrieval is recommended. Antigen retrieval with citrate buffer will enhance staining.

ターゲット情報

  • 機能
    Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo.
  • 組織特異性
    Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.
  • 配列類似性
    Belongs to the polyadenylate-binding protein type-1 family.
    Contains 1 PABC domain.
    Contains 4 RRM (RNA recognition motif) domains.
  • 翻訳後修飾
    Arg-518 is dimethylated, probably to asymmetric dimethylarginine.
  • 細胞内局在
    Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Activated platelet protein 1 antibody
    • Activated-platelet protein 1 antibody
    • APP 1 antibody
    • APP-1 antibody
    • APP1 antibody
    • FLJ43938 antibody
    • Inducible poly(A) binding protein antibody
    • Inducible poly(A)-binding protein antibody
    • iPABP antibody
    • IPABP4 antibody
    • PABP 4 antibody
    • PABP-4 antibody
    • PABP4 antibody
    • PABP4_HUMAN antibody
    • PABPC 4 antibody
    • PABPC4 antibody
    • Poly A binding protein cytoplasmic 4 antibody
    • Poly(A) binding protein 4 antibody
    • Poly(A) binding protein cytoplasmic 4 (inducible form) antibody
    • Poly(A) binding protein cytoplasmic 4 antibody
    • Poly(A)-binding protein 4 antibody
    • Polyadenylate binding protein 4 antibody
    • Polyadenylate-binding protein 4 antibody
    • Polyadenylate-binding protein, cytoplasmic, 4 antibody
    • Polyadenylate-binding protein, inducible antibody
    see all

画像

  • ab101492 at 1/250 dilution staining PABPC4 in a Formalin-fixed, paraffin-embedded section of Human ovarian carcinoma by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Detection utilised DAB.
  • ab101492 at 1/250 dilution staining PABPC4 in a formalin-fixed, paraffin-embedded section of mouse teratoma by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Detection utilised DAB.

プロトコール

参考文献

ab101492 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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