Anti-p75 NGF Receptor 抗体 [5C4B9] (ab86768)

製品の概要

  • 製品名Anti-p75 NGF Receptor antibody [5C4B9]
    p75 NGF Receptor 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [5C4B9] to p75 NGF Receptor
  • 特異性Please note that, despite having used an immunogen that is 100% homologous with the human and rat p75 NGF receptor proteins, Abcam could not get this antibody to detect p75 NGF receptor in human or rat tissue lysates. Abcam would welcome feedback from customers that have used ab86768 in either of these species!
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Human
  • 免疫原

    Synthetic peptide derived from within residues 250 - 350 of Human p75 NGF Receptor.

  • ポジティブ・コントロール
    • This antibody gave a positive signal in the following mouse tissue lysates: Brain; Spinal Cord; Heart.
  • 特記事項

    This antibody is available as an azide-free product (see ab175435).

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab86768 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 5 µg/ml. Detects a band of approximately 74 kDa (predicted molecular weight: 75 kDa).

ターゲット情報

  • 機能Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
  • 配列類似性Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • ドメインDeath domain is responsible for interaction with RANBP9.
    The extracellular domain is responsible for interaction with NTRK1.
  • 翻訳後修飾N- and O-glycosylated.
    O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
    Phosphorylated on serine residues.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD271 antibody
    • CD271 antigen antibody
    • Gp80 LNGFR antibody
    • Gp80-LNGFR antibody
    • Low affinity nerve growth factor receptor antibody
    • Low affinity neurotrophin receptor p75NTR antibody
    • Low-affinity nerve growth factor receptor antibody
    • Nerve growth factor receptor antibody
    • Nerve growth factor receptor TNFR superfamily member 16 antibody
    • NGF receptor antibody
    • Ngfr antibody
    • p75 ICD antibody
    • p75 Neurotrophin receptor antibody
    • p75 NTR antibody
    • p75(NTR) antibody
    • p75NTR antibody
    • TNFR Superfamily Member 16 antibody
    • TNFRSF16 antibody
    • TNR16_HUMAN antibody
    • Tumor necrosis factor receptor superfamily member 16 antibody
    see all

Anti-p75 NGF Receptor antibody [5C4B9] 画像

  • All lanes : Anti-p75 NGF Receptor antibody [5C4B9] (ab86768) at 5 µg/ml

    Lane 1 : Brain (Mouse) Tissue Lysate
    Lane 2 : Spinal Cord (Mouse) Tissue Lysate
    Lane 3 : Heart (Mouse) Tissue Lysate

    Lysates/proteins at 20 µg per lane.

    Secondary
    Goat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 75 kDa
    Observed band size : 74 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 30 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 16 minutes

Anti-p75 NGF Receptor antibody [5C4B9] (ab86768) 使用論文

ab86768 has not yet been referenced specifically in any publications.

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