製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to p73
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Chicken, Dog, Chimpanzee, Monkey
  • 免疫原

    A portion of amino acids 75-125 of human p73 protein.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab47100 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 68 kDa (predicted molecular weight: 70 kDa).

ターゲット情報

  • 機能
    Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
  • 組織特異性
    Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.
  • 配列類似性
    Belongs to the p53 family.
    Contains 1 SAM (sterile alpha motif) domain.
  • ドメイン
    Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL tyrosine kinase SH3 domain.
    The WW-binding motif mediates interaction with WWOX.
  • 翻訳後修飾
    Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity.
    Higher levels of phosphorylation seen in the brain from patients with Huntington disease.
    Ubiquitinated; leading to its degradation by the proteasome.
  • 細胞内局在
    Nucleus. Accumulates in the nucleus in response to DNA damage.
  • Information by UniProt
  • 参照データベース
  • 別名
    • p53 like transcription factor antibody
    • p53 related protein antibody
    • p53-like transcription factor antibody
    • p53-related protein antibody
    • p73 antibody
    • P73_HUMAN antibody
    • TP73 antibody
    • Tumor protein p73 antibody
    see all

画像

  • Anti-p73 antibody (ab47100) at 1 µg/ml + p73 transfected cell lysate

    Predicted band size : 70 kDa
    Observed band size : 68 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 36 kDa. We are unsure as to the identity of these extra bands.

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参考文献

ab47100 has not yet been referenced specifically in any publications.

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