Anti-p57 Kip2 抗体 - N-terminal, prediluted (ab99886)

製品の概要

  • 製品名
    Anti-p57 Kip2 antibody - N-terminal, prediluted
    p57 Kip2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to p57 Kip2 - N-terminal, prediluted
  • 由来種
    Rabbit
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic peptide corresponding to Human p57 Kip2 (N terminal).
    Database link: P49918

  • ポジティブ・コントロール
    • IHC-P: Human hydatid mole.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab99886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/1.

Ready to use.

Boil tissue section in 1mM EDTA, pH 8.0 for 10 minutes followed by cooling at RT for 20 minutes.

Incubate primary antibody for 30 minutes at room temperature.

 

ターゲット情報

  • 機能
    Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
  • 組織特異性
    Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.
  • 関連疾患
    Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
    Note=Defects in CDKN1C are involved in tumor formation.
  • 配列類似性
    Belongs to the CDI family.
  • 細胞内局在
    Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Beckwith Wiedemann syndrome antibody
    • BWCR antibody
    • BWS antibody
    • CDKI antibody
    • CDKN 1C antibody
    • CDKN1C antibody
    • CDN1C_HUMAN antibody
    • Cyclin dependent kinase inhibitor 1C antibody
    • Cyclin dependent kinase inhibitor p57 antibody
    • Cyclin-dependent kinase inhibitor 1C antibody
    • Cyclin-dependent kinase inhibitor p57 antibody
    • KIP 2 antibody
    • KIP2 antibody
    • p57 antibody
    • p57 Kip 2 antibody
    • p57KIP2 antibody
    • WBS antibody
    see all

画像

  • Formalin-fixed, paraffin-embedded human hydatid mole tissue stained for p57 Kip2 with ab99886 in immunohistochemical analysis.

参考文献

ab99886 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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