Anti-p57 Kip2 抗体 - N-terminal, prediluted (ab99886)
製品の概要
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製品名Anti-p57 Kip2 antibody - N-terminal, prediluted
p57 Kip2 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to p57 Kip2 - N-terminal, prediluted
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由来種Rabbit
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アプリケーション適用あり: IHC-Pmore details
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種交差性交差種: Human
交差が予測される動物種: Mouse, Rat
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免疫原
Synthetic peptide corresponding to Human p57 Kip2 (N terminal).
Database link: P49918 -
ポジティブ･コントロール
- IHC-P: Human hydatid mole.
製品の特性
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製品の状態Prediluted
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保存方法Shipped at 4°C. Store at +4°C. Do Not Freeze.
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バッファーpH: 7.60
Preservative: 0.099% Sodium azide
Constituents: 1% BSA, Tris buffered saline -
Concentration information loading... -
精製度Immunogen affinity purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab99886 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P | 1/1. Ready to use. Boil tissue section in 1mM EDTA, pH 8.0 for 10 minutes followed by cooling at RT for 20 minutes. Incubate primary antibody for 30 minutes at room temperature.
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ターゲット情報
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機能Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
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組織特異性Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.
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関連疾患Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
Note=Defects in CDKN1C are involved in tumor formation. -
配列類似性Belongs to the CDI family.
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細胞内局在Nucleus.
- Information by UniProt
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参照データベース
- Entrez Gene: 1028 Human
- Entrez Gene: 12577 Mouse
- Entrez Gene: 246060 Rat
- Omim: 600856 Human
- SwissProt: P49918 Human
- SwissProt: P49919 Mouse
- Unigene: 106070 Human
- Unigene: 168789 Mouse
see all -
別名
- Beckwith Wiedemann syndrome antibody
- BWCR antibody
- BWS antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - p57 Kip2 antibody, prediluted (ab99886)Formalin-fixed, paraffin-embedded human hydatid mole tissue stained for p57 Kip2 with ab99886 in immunohistochemical analysis.
参考文献
ab99886 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"