製品の概要

  • 製品名Anti-p57 Kip2 antibody
    p57 Kip2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to p57 Kip2
  • アプリケーション適用あり: IHC-Pmore details
    適用なし: WB
  • 種交差性
    交差種: Mouse, Cow, Human
  • 免疫原

    Synthetic peptide corresponding to Human p57 Kip2 (C terminal).

  • ポジティブ・コントロール
    • Colon carcinoma or placenta.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab80703 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 10 - 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Use at a concentration of 10 - 20 µg/ml for 30 min at RT. Perform heat mediated antigen retrieval by boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min, followed by cooling at RT for 20 min, before commencing with IHC staining protocol.

  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
    • 組織特異性Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.
    • 関連疾患Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
      Note=Defects in CDKN1C are involved in tumor formation.
    • 配列類似性Belongs to the CDI family.
    • 細胞内局在Nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Beckwith Wiedemann syndrome antibody
      • BWCR antibody
      • BWS antibody
      • CDKI antibody
      • CDKN 1C antibody
      • CDKN1C antibody
      • CDN1C_HUMAN antibody
      • Cyclin dependent kinase inhibitor 1C antibody
      • Cyclin dependent kinase inhibitor p57 antibody
      • Cyclin-dependent kinase inhibitor 1C antibody
      • Cyclin-dependent kinase inhibitor p57 antibody
      • KIP 2 antibody
      • KIP2 antibody
      • p57 antibody
      • p57 Kip 2 antibody
      • p57KIP2 antibody
      • WBS antibody
      see all

    Anti-p57 Kip2 antibody 画像

    • Formalin-fixed, paraffin-embedded human colon cancer stained with ab80703 at 20µg/ml using peroxidase-conjugate and AEC chromogen. Note nuclear staining of tumor cells.

    Anti-p57 Kip2 antibody (ab80703) 使用論文

    ab80703 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab80703.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"