製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to p53 BP3
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 995-1045 of Human p53 BP3 (NP_005793.2).

  • ポジティブ・コントロール
    • Human Breast Carcinoma, Placenta, Prostate Carcinoma and Testicular Seminoma tissues.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab113274 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

ターゲット情報

  • 機能
    Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
  • 組織特異性
    Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression is commonly decreased in colon adenocarcinomas and lung cancers.
  • 関連疾患
    Defects in TOPORS are the cause of retinitis pigmentosa type 31 (RP31) [MIM:609923]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP31 inheritance is autosomal dominant.
  • 配列類似性
    Contains 1 RING-type zinc finger.
  • 翻訳後修飾
    Phosphorylation at Ser-98 regulates the E3 ubiquitin-protein ligase activity but not the SUMO1-protein ligase activity. Phosphorylation at Ser-718 increases the E3 ubiquitin-protein ligase activity versus the SUMO1-protein ligase activity resulting in increased p53/TP53 ubiquitination and degradation.
    Sumoylated.
  • 細胞内局在
    Nucleus. Nucleus > PML body. Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AW105885 antibody
    • E3 ubiquitin protein ligase Topors antibody
    • E3 ubiquitin-protein ligase Topors antibody
    • LUN antibody
    • p53 binding protein 3 antibody
    • p53 BP3/LUN antibody
    • p53-binding protein 3 antibody
    • p53BP3 antibody
    • p53BP3/LUN antibody
    • Retinitis pigmentosa 31 antibody
    • RP31 antibody
    • SUMO1 protein E3 ligase Topors antibody
    • SUMO1-protein E3 ligase Topors antibody
    • Topoisomerase I binding arginine/serine rich antibody
    • Topoisomerase I binding arginine/serine rich protein antibody
    • Topoisomerase I binding protein antibody
    • Topoisomerase I binding RING finger protein antibody
    • Topoisomerase I-binding arginine/serine-rich protein antibody
    • Topoisomerase I-binding RING finger protein antibody
    • Topoisomerase I-binding RS protein antibody
    • Topors antibody
    • TOPRS_HUMAN antibody
    • TP53BPL antibody
    • Tumor protein p53 binding protein antibody
    • Tumor suppressor p53 binding protein 3 antibody
    • Tumor suppressor p53-binding protein 3 antibody
    see all

画像

  • ab113274 at 1/250 dilution staining p53 BP3 in Formalin-fixed, Paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry.
    Detection: DAB staining.
  • ab113274 at 1/100 dilution staining p53 BP3 in Formalin-fixed Paraffin-embedded Human breast carcinoma tissue by Immunofluorescence. Detection: Red-fluorescent Goat anti-Rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight® 594 Conjugated used at a dilution of 1/100.

プロトコール

参考文献

ab113274 has not yet been referenced specifically in any publications.

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