製品の概要

  • 製品名Anti-p150 CAF1 antibody
    p150 CAF1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to p150 CAF1
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Rhesus monkey, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region between residue 500 and 550 of Human p150 CAF1 (AAA76736.1).

  • ポジティブ・コントロール
    • Human colon, colonic lymphoid aggregate and colon carcinoma tissue

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab101286 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

ターゲット情報

  • 機能Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity). The CCR4-NOT complex functions as general transcription regulation complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.
  • 配列類似性Belongs to the CHAF1A family.
  • 発生段階Active complex is found in G1, S and G2 phases.
  • ドメインContains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Nucleus. DNA replication foci.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CAF 1 antibody
    • CAF 1 subunit A antibody
    • CAF antibody
    • CAF I 150 kDa subunit antibody
    • CAF I p150 antibody
    • CAF-1 subunit A antibody
    • CAF-I 150 kDa subunit antibody
    • CAF-I p150 antibody
    • CAF1 antibody
    • CAF1A_HUMAN antibody
    • CAF1B antibody
    • CAF1P150 antibody
    • CHAF1A antibody
    • Chromatin assembly factor 1 subunit A antibody
    • Chromatin Assembly Factor 1 Subunit A p150 antibody
    • Chromatin assembly factor I (150 kDa) antibody
    • Chromatin assembly factor I 150 kDa antibody
    • Chromatin assembly factor I p150 subunit antibody
    • DCAF1 antibody
    • hp150 antibody
    • MGC71229 antibody
    • P150 antibody
    see all

Anti-p150 CAF1 antibody 画像

  • ab101286, at 1/250 dilution, staining p150 CAF1 in a formalin-fixed paraffin-embedded section of Human colonic lymphoid aggregate by Immunohistochemistry using DAB staining.

Anti-p150 CAF1 antibody (ab101286) 使用論文

ab101286 has not yet been referenced specifically in any publications.

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