製品の概要

  • 製品名Anti-p130 antibody
  • 製品の詳細
    Mouse monoclonal to p130
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Orangutan
  • 免疫原

    Recombinant fragment: VTPVSTATHS LSRLHTMLTG LRNAPSEKLE QILRTCSRDP TQAIANRLKE MFEIYSQHFQ PDEDFSNCAK EIASKHFRFA EMLYYKVLES VIEQEQKRLG , corresponding to amino acids 416-516 of Human p130 with proprietary tag (NP_005602)

  • ポジティブ・コントロール
    • 293 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab89459 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 128 kDa (predicted molecular weight: 128 kDa).
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 関連性p130 is a key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
  • 細胞内局在Nuclear
  • 参照データベース
  • 別名
    • 130 kDa retinoblastoma associated protein antibody
    • IB4 antibody
    • PPAR alpha interacting complex protein 128 antibody
    • PRB2 antibody
    • PRIC128 antibody
    • RB2 antibody
    • RBL2 antibody
    • Retinoblastoma like 2 antibody
    • retinoblastoma like 2 (p130) antibody
    • Retinoblastoma like protein 2 antibody
    • RETINOBLASTOMA RELATED GENE RB2 antibody
    see all

Anti-p130 antibody 画像

  • Anti-p130 antibody (ab89459) at 1 µg/ml + 293 cell lysate at 50 µg

    Predicted band size : 128 kDa
    Observed band size : 128 kDa
  • Detection limit for recombinant tagged ab89459 is approximately 1ng/ml as a capture antibody

Anti-p130 antibody (ab89459) 使用論文

ab89459 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab89459.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"