製品の概要

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab59532 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent dilution. Predicted molecular weight: 121 kDa.

ターゲット情報

  • 機能Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
  • 配列類似性Belongs to the retinoblastoma protein (RB) family.
  • 翻訳後修飾Exists in both phosphorylated and unphosphorylated forms, and T, but not E1A, binds only to the unphosphorylated form. Cell-cycle arrest properties are inactivated by phosphorylation on Thr-332, Ser-640, Ser-964 and Ser-975 by CDK4.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 107 kDa retinoblastoma-associated protein antibody
    • Cellular protein 107 antibody
    • Cellular protein p107 antibody
    • CP107 antibody
    • MGC40006 antibody
    • p107 antibody
    • PRB1 antibody
    • RBL1 antibody
    • RBL1_HUMAN antibody
    • Retinoblastoma like protein 1 antibody
    • retinoblastoma-like 1 (p107) antibody
    • Retinoblastoma-like protein 1 antibody
    see all

Anti-p107 antibody (ab59532) 使用論文

ab59532 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"