Oxytocin, Reproductive hormone (ab120186)
Key features and details
- Reproductive hormone
- CAS Number: 50-56-6
- Soluble in water
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Oxytocin, Reproductive hormone -
製品の詳細
Reproductive hormone -
生理活性の詳細
Involved in many aspects of mammalian reproduction as well as other physiological processes such as bond pairing and cardiovascular homeostasis.
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CAS 番号
50-56-6 -
構造式
製品の特性
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分子量
1007.19 -
分子式
C43H66N12O12S2 -
配列
CYIQNCPLG (Modifications: C-terminal amide; Disulfide bonds: 1-6) -
PubChem 登録番号
439302 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab120186の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Functional Studies |
Use at an assay dependent concentration.
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特記事項 |
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Functional Studies
Use at an assay dependent concentration. |
画像
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2D chemical structure image of ab120186, Oxytocin, Reproductive hormone
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ab87312 staining oxytocin receptor in MCF7 cells treated with oxytocin (ab120186), by ICC/IF. Increase of cytoplasmatic oxytocin receptor localization and correspondent decrease in nuclear oxytocin receptor correlates with increased concentration of oxytocin, as described in literature.
The cells were incubated at 37°C for 15 minutes in media containing different concentrations of ab120186 (oxytocin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab87312 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 donkey anti-goat polyclonal antibody (ab96931) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (3)
ab120186 は 3 報の論文で使用されています。
- Rana M et al. Highly Specific Detection of Oxytocin in Saliva. Int J Mol Sci 24:N/A (2023). PubMed: 36902261
- Yuan J et al. The effects of oxytocin to rectify metabolic dysfunction in obese mice are associated with increased thermogenesis. Mol Cell Endocrinol 514:110903 (2020). PubMed: 32531419
- Yamagishi A et al. Oxytocin administration modulates rats' helping behavior depending on social context. Neurosci Res N/A:N/A (2019). PubMed: 30953682