Anti-Ovine MHC Class II DR 抗体 [37.68] (ab34007)

製品の概要

  • 製品名
    Anti-Ovine MHC Class II DR antibody [37.68]
  • 製品の詳細
    Mouse monoclonal [37.68] to Ovine MHC Class II DR
  • アプリケーション
    適用あり: Flow Cyt, IP, IHC-Frmore details
  • 種交差性
    交差種: Sheep, Goat, Cow, Human
  • 免疫原

    Splenocytes from ATL mice

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファー
    Preservative: 0.09% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 精製度
    Protein G purified
  • 特記事項(精製)
    Purified from tissue culture supernatant.
  • ポリ/モノ
    モノクローナル
  • クローン名
    37.68
  • アイソタイプ
    IgG2a
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab34007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use 10µl for 106 cells.

Use 1/50 - 1/200, or 10µl of the suggested working dilution to label 106 cells in 100µl.

ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

IP Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

ターゲット情報

  • 関連性
    Three subregions of the Major Histocompatibility Complex (MHC), DP, DQ and DR, determine class II molecules, which are essential in the cellular recognition interactions involved in the generation of an immune response. These molecules display processed antigens from virally-infected or transformed cells. Class-II-positive cells (antigen-presenting cells) can take up antigens from outside by endocytosis, degrade them into small peptides, and re-export the peptides (now bound to MHC class II protein) to the cell surface. These peptide-MHC class II complexes can then be recognized by specific CD4+ lymphocytes. Several class II antigens are also associated with disease states. The extremely high polymorphism of MHC class II transmembrane heterodimers is due to a few hypervariable segments present in the most external domain of their alpha and beta chains. The alpha chain of MHC-DR is not polymorphic, whereas the beta chain is highly so. Some changes in amino acid sequence are critical in disease susceptibility associations as well as the ability to present processed antigens to T cells.
  • 細胞内局在
    Cell Membrane
  • 別名
    • DR alpha chain antibody
    • DR beta 5 antibody
    • HLA class II histocompatibility antigen antibody
    • HLA DRA antibody
    • HLA DRB1 antibody
    • MHC class II antigen DRA antibody
    see all

参考文献

ab34007 has not yet been referenced specifically in any publications.

レビューと Q&A

We unfortunately cannot provide ab20147 and ab54217 as FITC conjugated antibodies because we do not custom conjugate the antibodies.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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