製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to OVCA1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Saccharomyces cerevisiae, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 35-84 (NQIPPEILKN PQLQAAIRVL PSNYNFEIPK TIWRIQQAQA KKVALQMPEG) of Human OVCA1 (NP_001374).

  • ポジティブ・コントロール
    • RPMI-8226 cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab101975 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 49 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival.
  • 組織特異性
    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors.
  • 配列類似性
    Belongs to the DPH1/DPH2 family. DPH1 subfamily.
  • 細胞内局在
    Nucleus. Cytoplasm. Punctate, primarily perinuclear localization.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Candidate tumor suppressor in ovarian cancer 1 antibody
    • Diphthamide biosynthesis protein 1 antibody
    • Diphthamide biosynthesis protein 2 homolog like 1 antibody
    • Diphthamide biosynthesis protein 2 homolog-like 1 antibody
    • Diphthamide biosynthesis protein 2 like antibody
    • Diphthamide biosynthesis protein 2-like antibody
    • Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces) like 1 antibody
    • Diptheria toxin resistance protein required for diphthamide biosynthesis like 1 antibody
    • DPH like 1 (S. cerevisiae) antibody
    • DPH like 1 antibody
    • DPH-like 1 antibody
    • DPH1 antibody
    • DPH1 homolog (S. cerevisiae) antibody
    • DPH1 homolog antibody
    • DPH1_HUMAN antibody
    • DPH2 like 1 antibody
    • DPH2-like 1 antibody
    • DPH2L antibody
    • DPH2L1 antibody
    • FLJ33211 antibody
    • HsDph1 antibody
    • Ovarian cancer associated gene 1 antibody
    • Ovarian cancer associated gene 1 protein antibody
    • Ovarian cancer-associated gene 1 protein antibody
    • Ovarian tumor suppressor candidate 1 antibody
    see all

画像

  • Anti-OVCA1 antibody (ab101975) at 1 µg/ml + RPMI-8226 cell lysate at 10 µg

    Predicted band size : 49 kDa

プロトコール

参考文献

ab101975 has not yet been referenced specifically in any publications.

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