- データシート
- 使用論文
製品の概要
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製品名Ouabain octahydrate
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製品の詳細Na+/K+ ATPase inhibitor
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生理活性の詳細Na+/K+ ATPase inhibitor (Ki = 30 μM). Cardiac glycoside. Stimulates activity at low nanomolar concentrations in rats. Improves cardiac function in myocardial infarction rats. Centrally active following oral administration.
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精製度> 97%
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特記事項
It has been reported that an aqueous solution of this material stored overnight in a borosilicate glass vial leads to the formation of ouabain-borate complexes.
It is therefore recommended that this material is stored in a plastic vial and any contact with borosilicate glass is minimised.
製品の特性
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体系名(1β,3β,5β,11α)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxycard-20(22)-enolide
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分子量728.78
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構造式
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分子式C29H44O12.8H2O
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CAS 番号11018-89-6
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保存方法Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
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溶解性Soluble in DMSO to 100 mM, in ethanol to 10 mM and in water to 10 mM.
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使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
ripe seeds of African plants Strophanthus gratus and the bark of Acokanthera ouabaio
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研究分野
参考文献
This product has been referenced in:
- Nelissen-Vrancken HJ et al. Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment. Naunyn Schmiedebergs Arch Pharmacol 356:203-9 (1997). Read more (PubMed: 9272726) »
- Blaustein MP Endogenous ouabain: role in the pathogenesis of hypertension. Kidney Int 49:1748-53 (1996). Read more (PubMed: 8743490) »
- Huang BS et al. Chronic central versus peripheral ouabain, blood pressure, and sympathetic activity in rats. Hypertension 23:1087-90 (1994). Read more (PubMed: 7911450) »
- Hara Y et al. Expression of active alpha-3 subunit of rat brain Na+,K+-ATPase from the messenger RNA injected into Xenopus oocytes. Biochem Biophys Res Commun 163:102-5 (1989). Read more (PubMed: 2549984) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"