製品の概要

  • 製品名Anti-OSTM1 antibody
    OSTM1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to OSTM1
  • アプリケーション適用あり: ICC/IF, WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen, corresponding to amino acids 225-278 (REAYKTLSSL YSEMQKMNEL ENKAEPGTHL CIDVEDAMNI TRKLWSRTFN CSVP) of Human OSTM1.

  • ポジティブ・コントロール
    • Human liver tissue; Transfected HEK293T cell lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab121327 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 1 - 4 µg/ml.
WB 1/250 - 1/500.
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Required for osteoclast and melanocyte maturation and function.
  • 関連疾患Defects in OSTM1 are the cause of osteopetrosis autosomal recessive type 5 (OPTB5) [MIM:259720]; also called infantile malignant osteopetrosis 3. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. OPTB5 patients manifest primary central nervous system involvement in addition to the classical stigmata of severe bone sclerosis, growth failure, anemia, thrombocytopenia and visual impairment with optic atrophy.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Chloride channel 7 beta subunit antibody
    • GAIP-interacting protein N terminus antibody
    • GIPN antibody
    • GL antibody
    • Grey lethal osteopetrosis antibody
    • HSPC019 antibody
    • OPTB5 antibody
    • Osteopetrosis-associated transmembrane protein 1 antibody
    • Ostm1 antibody
    • OSTM1_HUMAN antibody
    • OTTHUMP00000016938 antibody
    • OTTHUMP00000196342 antibody
    see all

Anti-OSTM1 antibody 画像

  • Immunocytochemistry/immunofluorescence analysis of A431 cells labelling OSTM1 with ab121327 shows positive staining in the nucleus, cytoplasm and vesicles.
  • All lanes : Anti-OSTM1 antibody (ab121327) at 1/250 dilution

    Lane 1 : Negative control (vector only transfected HEK293T lysate)
    Lane 2 : OSTM1-transfected HEK293T over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa))

    Developed using the ECL technique
  • ab121327, at 1/200, staining OSTM1 in paraffin embedded Human liver tissue by Immunohistochemistry.

Anti-OSTM1 antibody (ab121327) 使用論文

ab121327 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab121327.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"