Anti-Osteoprotegerin 抗体 [OPG-13] (ab2147)


  • 製品名Anti-Osteoprotegerin antibody [OPG-13]
    Osteoprotegerin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [OPG-13] to Osteoprotegerin
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide, corresponding to amino acids 21-39 of Human Osteoprotegerin.

  • 特記事項Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation. Sterile filtered and lyophilized from 2 mg/ml in 0.2 M phosphate buffer, 0.2 M NaCl, pH 7.2.



Our Abpromise guarantee covers the use of ab2147 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
  • 追加情報ELISA: 1/100000 when antibody is at a concentration of 1 mg/ml.
    WB: Use at an assay dependant dilution.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
    • 組織特異性Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
    • 関連疾患Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD) [MIM:239000]; also known as hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast-mediated skeletal resorption, the disease can be fatal.
    • 配列類似性Contains 2 death domains.
      Contains 4 TNFR-Cys repeats.
    • 翻訳後修飾N-glycosylated. Contains sialic acid residues.
      The N-terminus is blocked.
    • 細胞内局在Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • MGC29565 antibody
      • OCIF antibody
      • OPG antibody
      • Osteoclastogenesis inhibitory factor antibody
      • Osteoprotegerin antibody
      • PDB5 antibody
      • TNF receptor superfamily member 11b antibody
      • TNFRSF 11B antibody
      • TNFRSF11B antibody
      • TR 1 antibody
      • TR1 antibody
      • TR11B_HUMAN antibody
      • Tumor necrosis factor receptor superfamily member 11B antibody
      see all

    Anti-Osteoprotegerin antibody [OPG-13] (ab2147) 使用論文

    ab2147 has not yet been referenced specifically in any publications.

    Product Wall

    The product is monoclonal antibody against OPG peptide - against one epitope of the peptide. It is almost impossible for mouse to produce antibody against its own epitope. Also the sequences are different. However, we haven't tested it in mouse.

    I am afraid, our antibody is applicable only in Wesern Blotting. It is not likele to recognize OPG in formalin fixed tissue, because it is a monoclonal antibody and developed against short peptide, however, we didn't test it and don't intent to do so. ...

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