製品の概要

  • 製品名Anti-Osteoprotegerin antibody
    Osteoprotegerin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Osteoprotegerin
  • 特異性Detects endogenous levels of total Osteoprotegerin protein.
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide derived from internal sequence of human Osteoprotegerin

  • ポジティブ・コントロール
    • Extracts from 293 cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab65934 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
WB
  • 追加情報ELISA: 1/10000.
    WB: 1/500 - 1/1000. Detects a band of approximately 55 kDa (predicted molecular weight: 46 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
    • 組織特異性Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
    • 関連疾患Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD) [MIM:239000]; also known as hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast-mediated skeletal resorption, the disease can be fatal.
    • 配列類似性Contains 2 death domains.
      Contains 4 TNFR-Cys repeats.
    • 翻訳後修飾N-glycosylated. Contains sialic acid residues.
      The N-terminus is blocked.
    • 細胞内局在Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • MGC29565 antibody
      • OCIF antibody
      • OPG antibody
      • Osteoclastogenesis inhibitory factor antibody
      • Osteoprotegerin antibody
      • PDB5 antibody
      • TNF receptor superfamily member 11b antibody
      • TNFRSF 11B antibody
      • TNFRSF11B antibody
      • TR 1 antibody
      • TR1 antibody
      • TR11B_HUMAN antibody
      • Tumor necrosis factor receptor superfamily member 11B antibody
      see all

    Anti-Osteoprotegerin antibody 画像

    • All lanes : Anti-Osteoprotegerin antibody (ab65934) at 1/500 dilution

      Lane 1 : extracts from 293 cells
      Lane 2 : extracts from 293 cells with immunizing peptide at 10 µg

      Lysates/proteins at 30 µg per lane.


      Predicted band size : 46 kDa
      Observed band size : 55 kDa (why is the actual band size different from the predicted?)

    Anti-Osteoprotegerin antibody (ab65934) 使用論文

    ab65934 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab65934.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"