Anti-ORMDL3 抗体 (ab107639)

製品の概要

• 製品名
  Anti-ORMDL3 antibody
  ORMDL3 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to ORMDL3
• 特異性
  ab107639 may cross-react with ORMDL1 and ORMDL2.
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Mouse, Human
  
• 免疫原

  Synthetic peptide corresponding to Human ORMDL3 aa 53-81 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH).
  Database link: Q8N138

• ポジティブ･コントロール
  • WB: Mouse testis tissue lysate.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at 4°C (up to 6 months). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
• バッファー
  Preservative: 0.09% Sodium azide
  Constituent: PBS
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• 特記事項（精製）
  ab107639 is purified through a protein A column, followed by peptide affinity purification.
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Signal Transduction
  • Signaling Pathway
  • Calcium Signaling
  • Other

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Metabolism
  • Types of disease
  • Cancer

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能
  Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
• 組織特異性
  Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus.
• 関連疾患
  Genetic variations in ORMDL3 are associated with susceptibility to asthma (ASTHMA) [MIM:600807]. The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.
• 配列類似性
  Belongs to the ORM family.
• 細胞内局在
  Endoplasmic reticulum membrane.

• Target information above from: UniProt accession Q8N138 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 94103 Human
  • Entrez Gene: 66612 Mouse
  • Omim: 610075 Human
  • SwissProt: Q8N138 Human
  • SwissProt: Q9CPZ6 Mouse
  • Unigene: 514151 Human
  • Unigene: 180546 Mouse
• 別名
  • ORM1 (S. cerevisiae)-like 3 antibody
  • ORM1-like 3 (S. cerevisiae) antibody
  • ORM1-like 3 antibody

  • ORM1-like protein 3 antibody
  • ORMDL sphingolipid biosynthesis regulator 3 antibody
  • Ormdl3 antibody
  • ORML3_HUMAN antibody
  • OTTHUMP00000164334 antibody

  see all

プロトコール

• Western blot protocols