Anti-ORC6L 抗体 [3A4] - ChIP Grade (ab22536)

製品の概要

  • 製品名Anti-ORC6L antibody [3A4] - ChIP Grade
    ORC6L 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [3A4] to ORC6L - ChIP Grade
  • 特異性ab22536 recognises ORC6L.
  • アプリケーション適用あり: IP, WB, ChIPmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length protein (Human): ORC6L

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab22536 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 28 kDa.
ChIP Use at an assay dependent dilution.

ターゲット情報

  • 機能Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
  • 関連疾患Defects in ORC6 are the cause of Meier-Gorlin syndrome type 3 (MGORS3) [MIM:613803]. MGORS3 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
  • 配列類似性Belongs to the ORC6 family.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ORC 6 antibody
    • Orc6 antibody
    • ORC6_HUMAN antibody
    • ORC6L antibody
    • Origin recognition complex subunit 6 antibody
    • origin recognition complex subunit 6 homolog like antibody
    • origin recognition complex subunit 6 homolog like (yeast) antibody
    • origin recognition complex subunit 6 like (yeast) antibody
    see all

Anti-ORC6L antibody [3A4] - ChIP Grade (ab22536) 使用論文

ab22536 has not yet been referenced specifically in any publications.

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Thank you for your enquiry. At Abcam we qualify all of our "ChIP grade" antisera in two ways. Firstly we operate an in house ChIP testing programme with an in house development scientist. Secondly we collaborate with groups that have extensive experien...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"