製品の概要

  • 製品名Anti-Orai1 antibody
    Orai1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Orai1
  • アプリケーション適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide from the center region of Human Orai1 (NP_116179.2), conjugated to KLH.

  • ポジティブ・コントロール
    • A375 cell lysate, Mouse testis tissue lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)This antibody is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab86748 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100.
WB 1/1000. Predicted molecular weight: 33 kDa.

ターゲット情報

  • 機能Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
  • 関連疾患Defects in ORAI1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1) [MIM:612782]. IDTICED1 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, and normal lymphocytes counts and serum immunoglobulin levels. In surviving patients ectodermal dysplasia with anhydrosis and non-progressive myopathy may be observed.
  • 配列類似性Belongs to the Orai family.
  • 細胞内局在Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Calcium release activated calcium channel protein 1 antibody
    • Calcium release activated calcium modulator 1 antibody
    • Calcium release-activated calcium channel protein 1 antibody
    • CRACM 1 antibody
    • CRACM1 antibody
    • CRCM1 antibody
    • CRCM1_HUMAN antibody
    • FLJ14466 antibody
    • Orai 1 antibody
    • ORAI calcium release activated calcium modulator 1 antibody
    • orai1 antibody
    • ORAT1 antibody
    • Protein orai 1 antibody
    • Protein orai-1 antibody
    • TMEM 142A antibody
    • TMEM142A antibody
    • Transmembrane protein 142A antibody
    see all

Anti-Orai1 antibody 画像

  • All lanes : Anti-Orai1 antibody (ab86748) at 1/1000 dilution

    Lane 1 : A375 cell lysate
    Lane 2 : Mouse testis tissue lysate

    Lysates/proteins at 35 µg per lane.


    Predicted band size : 33 kDa
  • Immunohistochemical staining of formalin-fixed and paraffin-embedded human prostate carcinoma with ab86748 followed by a HRP-conjugated secondary antibody and DAB staining.

Anti-Orai1 antibody (ab86748) 使用論文

ab86748 has not yet been referenced specifically in any publications.

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N-linked protein glycosylation (N-glycosylation of N-glycans) can occur at Asn residues (Asn-x-Ser/Thr motifs) in glycoproteins. The shift between the theoretical and the actual band size depends on the cell type, ...

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Western blotting is a technique that separates proteins based on size. In general, the smaller the protein the faster it migrates through the gel. However, migration is also affected by other fact...

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