製品の概要
- 製品名Anti-Optineurin antibody
Optineurin 一次抗体 製品一覧 - 製品の詳細Rabbit polyclonal to Optineurin
- アプリケーション適用あり: WB, IHC-Pmore details
- 種交差性交差種: Human
交差が予測される動物種: Cynomolgus monkey, Macaque monkey, Orangutan
非交差種:
Mouse, Rat, Pig - 免疫原
Synthetic peptide:
KGKSERSSEDPTDDSR
, corresponding to amino acids 115-130 of Human Optineurin - ポジティブ･コントロール
- Adrenal tissue.
製品の特性
- 製品の状態Liquid
- 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
- バッファーPreservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, Tris buffered saline, 0.5mg/ml BSA, pH 7.4 -
Concentration information loading... - 精製度Immunogen affinity purified
- ポリ/モノポリクローナル
- アイソタイプIgG
- 研究分野
関連製品
- Compatible Secondaries
- Positive Controls
アプリケーション
Our Abpromise guarantee covers the use of ab79110 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | Use at an assay dependent concentration. Predicted molecular weight: 66 kDa. | |
| IHC-P | Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
- 機能Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.
- 組織特異性Present in acqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.
- 関連疾患Defects in OPTN are the cause of primary open angle glaucoma type 1E (GLC1E) [MIM:137760]. Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
Defects in OPTN are a cause of susceptibility to normal pressure glaucoma (NPG) [MIM:606657].
Defects in OPTN are the cause of amyotrophic lateral sclerosis type 12 (ALS12) [MIM:613435]. It is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. - ドメインUbiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.
- 翻訳後修飾Phosphorylated. Phosphorylation is induced by phorbol esters and decreases its half-time.
- 細胞内局在Cytoplasm > perinuclear region. Golgi apparatus. Golgi apparatus > trans-Golgi network. Found in the perinuclear region and associates with the Golgi apparatus. Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane.
- Information by UniProt
-
参照データベース
- Entrez Gene: 10133 Human
- Omim: 602432 Human
- SwissProt: Q95KA2 Cynomolgus monkey
- SwissProt: Q96CV9 Human
- SwissProt: Q5R923 Orangutan
- Unigene: 332706 Human
-
別名
- 14.7K interacting protein antibody
- Ag9 C5 antibody
- ALS12 antibody
see all
Anti-Optineurin antibody 画像
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Optineurin antibody (ab79110)Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human adrenal tissue, staining Optineurin with ab79110 at 5 µg/ml.
Anti-Optineurin antibody (ab79110) 使用論文
ab79110 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"