製品の概要

  • 製品名OMDM-2
  • 製品の詳細
    Potent, selective anandamide reuptake inhibitor
  • 生理活性の詳細Potent, selective cellular uptake inhibitor of anandamide (IC50 = 4.9 μM in primary culture). Able to inhibit FAAH (Ki = 9.7 μM). Poor affinity for CB1 and CB2 receptors (Ki = 5 and >10 μM, respectively) and no activity at vannilloid VR1 receptors (EC50 = >10 μM).
  • 精製度> 98%

製品の特性

  • 体系名(R)-N-(1-(4-Hydroxyphenyl)-2-hydroxyethyl)oleamide
  • 分子量431.66
  • 構造式Chemical Structure
  • 分子式C27H45NO3
  • CAS 番号616884-63-0
  • 保存方法Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性Soluble in ethanol and DMSO to 50 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記CCCCCCCC/C=CCCCCCCCC(=O)N[C@@H](CO)Cc1ccc(O)cc1
  • 由来

    Synthetic

  • 研究分野

    OMDM-2 (ab120877) 使用論文

    This product has been referenced in:
    • Lewis DY & Brett RR Activity-based anorexia in C57/BL6 mice: effects of the phytocannabinoid, Delta9-tetrahydrocannabinol (THC) and the anandamide analogue, OMDM-2. Eur Neuropsychopharmacol 20:622-31 (2010). Read more (PubMed: 20471226) »
    • Hillard CJ  et al. Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolase. J Mol Neurosci 33:18-24 (2007). Read more (PubMed: 17901541) »
    • de Lago E  et al. In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake. Eur J Pharmacol 484:249-57 (2004). Read more (PubMed: 14744610) »
    • Ortar G  et al. Novel selective and metabolically stable inhibitors of anandamide cellular uptake. Biochem Pharmacol 65:1473-81 (2003). Read more (PubMed: 12732359) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"