Anti-OGR1 抗体 (ab61420)
Key features and details
- Rabbit polyclonal to OGR1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-OGR1 antibody
OGR1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to OGR1 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse -
免疫原
Synthetic peptide corresponding to Human OGR1 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH).
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ポジティブ・コントロール
- Human Testis.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.70
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab61420の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P | (1) |
Use a concentration of 20 µg/ml.
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特記事項 |
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IHC-P
Use a concentration of 20 µg/ml. |
ターゲット情報
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機能
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer. -
組織特異性
Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 8111 Human
- Entrez Gene: 238377 Mouse
- Omim: 601404 Human
- SwissProt: Q15743 Human
- SwissProt: Q8BFQ3 Mouse
- Unigene: 8882 Human
- Unigene: 32160 Mouse
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別名
- G protein coupled receptor 68 antibody
- G-protein coupled receptor 68 antibody
- GPR 12A antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab61420 は 2 報の論文で使用されています。
- Herzig M et al. Comprehensive Assessment of GPR68 Expression in Normal and Neoplastic Human Tissues Using a Novel Rabbit Monoclonal Antibody. Int J Mol Sci 20:N/A (2019). PubMed: 31652823
- Wiley SZ et al. GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells. FASEB J 32:1170-1183 (2018). PubMed: 29092903