製品の概要

  • 製品名Anti-OFD1 antibody
  • 製品の詳細
    Rabbit polyclonal to OFD1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Rat
    交差が予測される動物種: Mouse, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Human
  • 免疫原

    Synthetic peptide corresponding to a region within N-terminal amino acids 2-51 (AQSTMPHKCD DVLSQDELRK KLYQTFKDRG ILDTLKTQLR NQLVHELMHP) of Rat OFD1 (NP_001100431).

  • ポジティブ・コントロール
    • Rat liver lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab122960 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 118 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation.
  • 組織特異性Widely expressed. Expressed in 9 and 14 weeks old embryos in metanephric mesenchyme, oral mucosa, lung, heart, nasal and cranial cartilage, and brain. Expressed in metanephros, brain, tongue, and limb.
  • 関連疾患Orofaciodigital syndrome 1
    Simpson-Golabi-Behmel syndrome 2
    Joubert syndrome 10
    Retinitis pigmentosa 23
  • 配列類似性Belongs to the OFD1 family.
    Contains 1 LisH domain.
  • 細胞内局在Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Localizes to centriole distal ends and to centriolar satellites (PubMed:20230748, PubMed:24121310).
  • Information by UniProt
  • 参照データベース
  • 別名
    • 71 7A antibody
    • 717A antibody
    • CXorf5 antibody
    • JBTS10 antibody
    • Ofd1 antibody
    • OFD1_HUMAN antibody
    • oral facial digital syndrome 1 antibody
    • Oral-facial-digital syndrome 1 protein antibody
    • OTTHUMP00000022941 antibody
    • Protein 71-7A antibody
    • RGD1562231 antibody
    • SGBS2 antibody
    see all

Anti-OFD1 antibody 画像

  • Anti-OFD1 antibody (ab122960) at 1 µg/ml + Rat liver lysate at 10 µg

    Predicted band size : 118 kDa

Anti-OFD1 antibody (ab122960) 使用論文

ab122960 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"