製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to OBSCN
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 4984-5126 of Human OBSCN.

  • ポジティブ・コントロール
    • Human skeletal muscle tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab121652 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/2500 - 1/5000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
  • 配列類似性
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 DH (DBL-homology) domain.
    Contains 3 fibronectin type-III domains.
    Contains 55 Ig-like (immunoglobulin-like) domains.
    Contains 1 IQ domain.
    Contains 2 PH domains.
    Contains 2 protein kinase domains.
    Contains 1 SH3 domain.
  • 細胞内局在
    Cytoplasm > myofibril > sarcomere > M line. Cytoplasm > myofibril > sarcomere > Z line. In differentiating skeletal muscle cells, isoform 3 primarily localizes to the sarcomeric M-line and less frequently to the Z-disk. Isoform 3 colocalizes with ANK1 isoform Mu17/ank1.5 at the M-line in differentiated skeletal muscle cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BC046431 antibody
    • Gm878 antibody
    • KIAA1556 antibody
    • KIAA1639 antibody
    • OBSCN antibody
    • OBSCN_HUMAN antibody
    • Obscurin antibody
    • Obscurin-MLCK antibody
    • Obscurin-myosin light chain kinase antibody
    • Obscurin-RhoGEF antibody
    • OTTMUSG00000005786 antibody
    • UNC89 antibody
    see all

画像

  • ab121652, at 1/3500 dilution, staining OBSCN in paraffin-embedded Human skeletal muscle tissue by Immunohistochemistry.

プロトコール

参考文献

ab121652 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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