Anti-OATP1B1 抗体 [MDQ] (ab15442)
Key features and details
- Mouse monoclonal [MDQ] to OATP1B1
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-OATP1B1 antibody [MDQ]
OATP1B1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [MDQ] to OATP1B1 -
由来種
Mouse -
特異性
Ab15442 will also cross react with OATP8. -
アプリケーション
適用あり: ICC/IFmore details -
種交差性
交差種: Human
非交差種: Mouse, Rat, Dog -
免疫原
Synthetic peptide corresponding to Human OATP1B1 aa 1-23.
Sequence:MDQNQHLNKTAEAQPSENKKTRY
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ポジティブ・コントロール
- Human liver tissue slides.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.09% Sodium azide -
Concentration information loading...
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精製度
Tissue culture supernatant -
ポリ/モノ
モノクローナル -
クローン名
MDQ -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab15442の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC/IF |
1/20.
|
特記事項 |
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ICC/IF
1/20. |
ターゲット情報
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機能
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver. -
組織特異性
Highly expressed in liver. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte. -
配列類似性
Belongs to the organo anion transporter (TC 2.A.60) family.
Contains 1 Kazal-like domain. -
細胞内局在
Basolateral cell membrane. Detected in basolateral membranes of hepatocytes. - Information by UniProt
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参照データベース
- Entrez Gene: 10599 Human
- Omim: 604843 Human
- SwissProt: Q9Y6L6 Human
- Unigene: 449738 Human
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別名
- Liver-specific organic anion transporter 1 antibody
- LST-1 antibody
- LST1 antibody
see all
画像
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Immunocytochemistry/Immunofluorescence analysis of HepG2 cells labeling OATP1B1 (green) with ab15542 at 1/20. F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue). Cells were fixed with formaldehyde and incubated with the primary antibody overnight at 4°C. A DyLight 488-conjugated secondary antibody was used. 60X magnification. Right - negative control.
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (3)
ab15442 は 3 報の論文で使用されています。
- Imada S et al. Central bisectionectomy for hepatocellular carcinoma in a patient with indocyanine green excretory defect associated with reduced expression of the liver transporter. Surg Case Rep 2:89 (2016). PubMed: 27589984
- Peng JF et al. Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid. Biomol Ther (Seoul) 23:400-6 (2015). WB . PubMed: 26336578
- Sticova E et al. Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis. Int J Clin Exp Pathol 8:5252-62 (2015). PubMed: 26191226