製品の概要

  • 製品名Anti-OATP2 antibody [ESL]
    OATP2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [ESL] to OATP2
  • 特異性This antibody shows no cross-reactivity to other OATP isoforms.
  • アプリケーション適用あり: IHC-P, ICC/IF, WB, IPmore details
  • 種交差性
    交差種: Human, Xenopus laevis
    非交差種: Mouse, Rat, Dog
  • 免疫原

    Synthetic peptide corresponding to Human OATP2 aa 671-691.
    Sequence:

    ESLNKNKHFVPSAGADSETHC

  • ポジティブ・コントロール
    • Human liver tissue slides.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab15441 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.
ICC/IF 1/100. PubMed: 21173039
WB 1/1000.
IP Use at an assay dependent concentration.

ターゲット情報

  • 機能Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver.
  • 組織特異性Highly expressed in liver. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.
  • 配列類似性Belongs to the organo anion transporter (TC 2.A.60) family.
    Contains 1 Kazal-like domain.
  • 細胞内局在Basolateral cell membrane. Detected in basolateral membranes of hepatocytes.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Liver-specific organic anion transporter 1 antibody
    • LST-1 antibody
    • LST1 antibody
    • OATP-2 antibody
    • OATP-C antibody
    • OATP1B1 antibody
    • OATPC antibody
    • SLC21A6 antibody
    • SLCO1B1 antibody
    • SO1B1_HUMAN antibody
    • Sodium-independent organic anion-transporting polypeptide 2 antibody
    • Solute carrier family 21 member 6 antibody
    • Solute carrier organic anion transporter family member 1B1 antibody
    see all

Anti-OATP2 antibody [ESL] (ab15441) 使用論文

This product has been referenced in:
  • van de Steeg E  et al. Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of OATP1B1. Drug Metab Dispos 41:592-601 (2013). ICC/IF ; Human . Read more (PubMed: 23248200) »
  • Martinez-Becerra P  et al. Further Characterization of the Electrogenicity and pH Sensitivity of the Human Organic Anion-Transporting Polypeptides OATP1B1 and OATP1B3. Mol Pharmacol 79:596-607 (2011). ICC/IF ; Xenopus laevis . Read more (PubMed: 21173039) »

See all 2 Publications for this product

Product Wall



Any products that require an MSDS form will have a link on the product's online datasheet to the data. It will be a PDF document link labeled 'SDS'. Please see attached image for example of what to look for on the datasheet. If no 'SDS' link ...

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Thank you for getting back to me with this case.

I am glad that the customer has received the replacement product. I can confirm that this antibody has detected a band of ˜85 kDa in liver basolateral membrane as well as a band of ˜90 kDa in t...

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Thank you for your enquiry. Both antibodies were tested in IP using human liver samples (~20-50 ug) and about 1 ug/ml of antibody used. For IF, human liver and transfected HEK293 whole cell lysates were used. Ab15442 was used at a dilution of 1:20. The...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"