製品の概要

  • 製品名
    O-1918
  • 製品の詳細
    Antagonist of the non-CB1 vascular cannabinoid receptor
  • 生理活性の詳細
    Silent antagonist of the non-CB1 vascular cannabinoid receptor (the 'Abn-CBD' receptor recently reported to be GPR18). Cannabidiol antagonist. Blocks Abn-CBD induced potentiation of a Ca2+-activated K+ current in human umbilical vein endothelial cells.
  • 精製度
    > 97%
  • 特記事項
    Sold under license from Virginia Commonwealth University.

製品の特性

参考文献

This product has been referenced in:
  • Zakrzeska A  et al. A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats. Br J Pharmacol 160:574-84 (2010). Read more (PubMed: 20105178) »
  • McHugh D  et al. N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor. BMC Neurosci 11:44 (2010). Read more (PubMed: 20346144) »
  • Offertáler L  et al. Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol Pharmacol 63:699-705 (2003). Read more (PubMed: 12606780) »
  • Begg M  et al. G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current. J Biol Chem 278:46188-94 (2003). Read more (PubMed: 12952947) »

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