製品の概要

  • 製品名Anti-NUMBL antibody - N-terminal
    NUMBL 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to NUMBL - N-terminal
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    KLH-conjugated synthetic peptide from the N-terminal region of Human NUMBL

  • ポジティブ・コントロール
    • Human lung carcinoma tissue

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Ammonium Sulphate Precipitation
  • 特記事項(精製)Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab80119 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
IHC-P 1/10 - 1/50.

ターゲット情報

  • 機能Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
  • 配列類似性Contains 1 PID domain.
  • ドメインThe PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B.
  • 細胞内局在Cytoplasm. Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CAG 3A antibody
    • CAG3A antibody
    • CTG 3a antibody
    • CTG3a antibody
    • NBL antibody
    • NUMB Drosophilia Homolog Like antibody
    • Numb homolog (Drosophila) like antibody
    • Numb homolog like antibody
    • Numb like protein antibody
    • NUMB R antibody
    • Numb-like protein antibody
    • Numb-R antibody
    • Numb-related gene antibody
    • Numb-related protein antibody
    • NUMBL antibody
    • NUMBL_HUMAN antibody
    • NUMBLIKE antibody
    • NUMBR antibody
    • TNRC 23 antibody
    • TNRC23 antibody
    • Trinucleotide repeat-containing gene 23 antibody
    see all

Anti-NUMBL antibody - N-terminal 画像

  • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human lung carcinoma tissue using 1/10 ab80122, in conjunction with a peroxidase-conjugated secondary antibody, followed by DAB staining.

Anti-NUMBL antibody - N-terminal (ab80119) 使用論文

ab80119 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"