製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to NUMBL
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 571-600 of Human NUMBL (NP_004747.1).

  • ポジティブ・コントロール
    • 293 cell line lysates.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファー
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    ab116296 is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab116296 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 65 kDa.

ターゲット情報

  • 機能
    Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
  • 配列類似性
    Contains 1 PID domain.
  • ドメイン
    The PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B.
  • 細胞内局在
    Cytoplasm. Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CAG 3A antibody
    • CAG3A antibody
    • CTG 3a antibody
    • CTG3a antibody
    • NBL antibody
    • NUMB Drosophilia Homolog Like antibody
    • Numb homolog (Drosophila) like antibody
    • Numb homolog like antibody
    • Numb like protein antibody
    • NUMB R antibody
    • Numb-like protein antibody
    • Numb-R antibody
    • Numb-related gene antibody
    • Numb-related protein antibody
    • NUMBL antibody
    • NUMBL_HUMAN antibody
    • NUMBLIKE antibody
    • NUMBR antibody
    • TNRC 23 antibody
    • TNRC23 antibody
    • Trinucleotide repeat-containing gene 23 antibody
    see all

画像

  • Anti-NUMBL antibody (ab116296) at 1/100 dilution + 293 cell line lysates at 35 µg

    Predicted band size : 65 kDa

プロトコール

参考文献

ab116296 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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