製品の概要

  • 製品名
    Anti-Nucleostemin antibody
    Nucleostemin 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Nucleostemin
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rabbit, Horse, Dog, Chimpanzee
  • 免疫原

    Synthetic peptide corresponding to a region between residue 500 and the C terminus (residue 549) of human Nucleostemin (accession number: NP_055181.3)

  • ポジティブ・コントロール
    • Human skin basal cell carcinoma; mouse squamous cell carcinoma

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab84363 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100 - 1/500. Antigen retrieval is not essential but may optimise staining. The use of citrate buffer will enhance staining.

ターゲット情報

  • 機能
    May be required to maintain the proliferative capacity of stem cells and may play an important role in tumorigenesis.
  • 組織特異性
    Increased levels in lung tissue in cancer patients.
  • 配列類似性
    Belongs to the MMR1/HSR1 GTP-binding protein family.
    Contains 1 G (guanine nucleotide-binding) domain.
  • ドメイン
    The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis.
    In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.
  • 細胞内局在
    Nucleus. Nucleus > nucleolus. Shuttles between the nucleus and nucleolus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • C77032 antibody
    • E2 induced gene 3 protein antibody
    • E2-induced gene 3 protein antibody
    • E2IG3 antibody
    • Estradiol induced nucleotide binding protein antibody
    • GNL3 antibody
    • GNL3_HUMAN antibody
    • Guanine nucleotide binding protein like 3 (nucleolar) antibody
    • Guanine nucleotide binding protein like 3 antibody
    • Guanine nucleotide-binding protein-like 3 antibody
    • MGC800 antibody
    • NNP47 antibody
    • Novel nucleolar protein 47 antibody
    • NS antibody
    • Nucleolar GTP binding protein 3 antibody
    • Nucleolar GTP-binding protein 3 antibody
    • Nucleostemin antibody
    • Putative nucleotide binding protein estradiol induced antibody
    see all

画像

  • Detection of Human Nucleostemin in formalin-fixed paraffin-embedded section of human skin basal cell carcinoma by Immunohistochemistry using ab84363 at a dilution of 1:500. Detection was performed by DAB staining using anti-Rabbit IHC antibody at a dilution of 1:100.
  • Detection of Human Nucleostemin in formalin-fixed paraffin-embedded section of section of mouse squamous cell carcinoma by Immunohistochemistry using ab84363 at a dilution of 1:100. Detection was performed by DAB staining using anti-Rabbit IHC antibody at a dilution of 1:100.

プロトコール

参考文献

ab84363 has not yet been referenced specifically in any publications.

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