Nuclear Receptor Corepressor NCoR peptide (ab4997)

製品の概要

製品の詳細

  • 由来
    Synthetic

特性

Our Abpromise guarantee covers the use of ab4997 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • 備考


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and N-CoR, catalog ab3482. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • hN CoR
    • hNCoR
    • KIAA1047
    • N CoR
    • N Cor/SMRT corepressor Rip13
    • N CoR1
    • N-CoR
    • N-CoR1
    • NCoR
    • NCOR 1
    • Ncor1
    • NCOR1_HUMAN
    • Nuclear receptor co repressor 1
    • Nuclear receptor corepressor 1
    • Retinoid X receptor interacting protein 13
    • RIP13
    • Rxrip13
    • thyroid hormone and retinoic acid receptor associated corepressor 1
    • TRAC 1
    • TRAC1
    see all
  • 機能
    Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.
  • 配列類似性
    Belongs to the N-CoR nuclear receptor corepressors family.
    Contains 2 SANT domains.
  • ドメイン
    The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).
    The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity.
  • 翻訳後修飾
    Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

参考文献

ab4997 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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