Anti-Nuclear Matrix Protein p84 抗体 [5E10] (ab94812)


  • 製品名Anti-Nuclear Matrix Protein p84 antibody [5E10]
    Nuclear Matrix Protein p84 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [5E10] to Nuclear Matrix Protein p84
  • 特異性ab94812 recognizes an 84 kD nuclear matrix protein that was first discovered through its association with the N terminal region of retinoblastoma protein.
  • アプリケーション適用あり: IP, ICC/IF, WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Fusion protein, corresponding to amino acids 15 - 374 of Human Nuclear Matrix Protein p84, expressed in E. coli.

  • ポジティブ・コントロール
    • Molt 4, HeLa and Raji cell lysates




Our Abpromise guarantee covers the use of ab94812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use a concentration of 0.5 - 2 µg/ml.
ICC/IF Use a concentration of 0.5 - 2 µg/ml.
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 84 kDa (predicted molecular weight: 76 kDa).


  • 機能Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4.
    Regulates transcriptional elongation of a subset of genes. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1.
  • 組織特異性Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotype of breast tumors and expression correlates with tumor size and the metastatic state of the tumor progression.
  • 配列類似性Contains 1 death domain.
  • ドメインAn intact death domain is needed for apoptosis.
  • 翻訳後修飾Expression is altered specifically during apoptosis and is accompanied by the appearance of novel forms with smaller apparent molecular mass.
  • 細胞内局在Cytoplasm and Nucleus speckle. Nucleus > nucleoplasm. Nucleus matrix. Cytoplasm. Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution.
  • Information by UniProt
  • 参照データベース
  • 製品の状態Nuclear (Isoform 1) and Cytoplasmic (Isoform 1 and 2).
  • 別名
    • hTREX84 antibody
    • Death domain containing protein p84N5 antibody
    • HPR 1 antibody
    • HPR1 antibody
    • hTREX84 antibody
    • Nuclear matrix protein p84 antibody
    • P84 antibody
    • p84N5 antibody
    • Tho 1 antibody
    • THO complex 1 antibody
    • THO complex subunit 1 antibody
    • Tho1 antibody
    • THOC 1 antibody
    • Thoc1 antibody
    • THOC1_HUMAN antibody
    see all

Anti-Nuclear Matrix Protein p84 antibody [5E10] (ab94812) 使用論文

ab94812 has not yet been referenced specifically in any publications.

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