Anti-Nuclear Factor Erythroid Derived 2 抗体 (ab116057)


  • 製品名Anti-Nuclear Factor Erythroid Derived 2 antibody
    Nuclear Factor Erythroid Derived 2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Nuclear Factor Erythroid Derived 2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 311-340 of Human Nuclear Factor Erythroid Derived 2 (NP_006154.1, NP_001129495.1).

  • ポジティブ・コントロール
    • MDA-MB435 cell line lysates.



Our Abpromise guarantee covers the use of ab116057 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 41 kDa.


  • 機能Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
  • 組織特異性Expressed in hematopoietic cells and also in colon and testis.
  • 配列類似性Belongs to the bZIP family. CNC subfamily.
    Contains 1 bZIP domain.
  • ドメインThe PXY motifs are required for binding WW domains. PXY1 is required to promote transactivation of beta-globin and for hyperacetylation of histone H3, but not for binding to the HS2 promoter site.
  • 翻訳後修飾Phosphorylated on serine residues (By similarity). In undifferentiated erythrocytes, phosphorylated by MAPK8 which then leads to ubiquitination and protein degradation.
    Sumoylated. Sumoylation is required for translocation to nuclear bodies PODs, anchoring to the gene loci, and transactivation of the beta-globin gene.
    Ubiquitinated mainly by 'Lys63'-linked ubiquitin. Polyubiquitination with 'Lys63'-linked ubiquitin by ITCH retains NFE2 in the cytoplasm preventing its transactivation activity. In undifferentiated erythrocyte, ubiquitinated after MAPK8-mediatd phosphorylation leading to protein degradation.
  • 細胞内局在Nucleus > PML body. Cytoplasm. The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.
  • Information by UniProt
  • 参照データベース
  • 別名
    • erythroid-derived 2 45 kDa subunit antibody
    • Leucine zipper protein NF-E2 antibody
    • Leucine zipper protein NFE2 antibody
    • NF E2 antibody
    • nfe2 antibody
    • NFE2_HUMAN antibody
    • Nuclear factor (erythroid derived 2), 45kDa antibody
    • nuclear factor (erythroid-derived 2), 45kD antibody
    • Nuclear factor antibody
    • nuclear factor, erythroid 2 antibody
    • Nuclear factor, erythroid derived 2 45 kDa subunit antibody
    • p45 antibody
    • p45 NF-E2 antibody
    • p45 NFE2 antibody
    • Transcription factor NF-E2 45 kDa subunit antibody
    • Transcription factor NFE2 45 kDa subunit antibody
    see all

Anti-Nuclear Factor Erythroid Derived 2 antibody 画像

  • Anti-Nuclear Factor Erythroid Derived 2 antibody (ab116057) at 1/100 dilution + MDA-MB435 cell line lysates at 35 µg

    Predicted band size : 41 kDa

Anti-Nuclear Factor Erythroid Derived 2 antibody (ab116057) 使用論文

ab116057 has not yet been referenced specifically in any publications.

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