生理活性の詳細Novel, specific, reversible DNA-dependent protein kinase (DNA-PK) inhibitor (IC50 = 0.23 μM). Increases G2/M arrest and inhibits double-strand break repair.
保存方法Store at +4°C. The product can be stored for up to 12 months.
溶解性Soluble in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Baleriola J et al. DNA-PK promotes the survival of young neurons in the embryonic mouse retina. Cell Death Differ17:1697-706 (2010).
Read more (PubMed: 20448641) »
Amrein L et al. Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. J Pharmacol Exp Ther321:848-55 (2007).
Read more (PubMed: 17351105) »
Nutley BP et al. Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026. Br J Cancer93:1011-8 (2005).
Read more (PubMed: 16249792) »