製品の概要

  • 製品名Anti-NTE antibody
    NTE 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to NTE
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Recombinant Fragment
    交差が予測される動物種: Mouse, Cow, Human, Orangutan
  • 免疫原

    Recombinant fragment: ESRRADVLAF PSSGFTDLAE IVSRIEPPTS YVSDGCADGE ESDCLTEYEE DAGPDCSRDE GGSPEGASPS TASEMEEEKS ILRQRRCLPQ EPPGSATDA, corresponding to amino acids 1229-1327 of Human NTE with a tag of 26 kDa.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab77153 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報ELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 150 kDa.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.



    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.
    • 組織特異性Expressed in brain, placenta, kidney, neuron and skeletal muscle.
    • 関連疾患Defects in PNPLA6 are the cause of spastic paraplegia autosomal recessive type 39 (SPG39) [MIM:612020]; also known as NTE-related motor neuron disorder (NTEMND). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG39 is associated with a motor axonopathy affecting upper and lower limbs and resulting in progressive wasting of distal upper and lower extremity muscles.
    • 配列類似性Belongs to the NTE family.
      Contains 3 cyclic nucleotide-binding domains.
      Contains 1 patatin domain.
    • 翻訳後修飾Glycosylated.
    • 細胞内局在Endoplasmic reticulum membrane. Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment.
    • Information by UniProt
    • 参照データベース
    • 別名
      • EC 3.1.1.5 antibody
      • Neuropathy target esterase antibody
      • NTEMND antibody
      • Patatin like phospholipase domain containing 6 antibody
      • Patatin like phospholipase domain containing protein 6 antibody
      • Patatin-like phospholipase domain-containing protein 6 antibody
      • PLPL6_HUMAN antibody
      • Pnpla6 antibody
      • SPG39 antibody
      • sws antibody
      see all

    Anti-NTE antibody 画像

    • Anti-NTE antibody (ab77153) at 5 µg/ml + immunogen at 0.2 µg

      Secondary
      Goat anti-mouse IgG (H&L)-HRP conjugate at 1/5000 dilution
      Developed using the ECL technique

      Predicted band size : 150 kDa
      Observed band size : 37 kDa (why is the actual band size different from the predicted?)

    Anti-NTE antibody (ab77153) 使用論文

    ab77153 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab77153.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"