Potent activator of human Ca2+ -activated K+ channels of SK and IK types, selective over BK type channels (EC50 = 10 nM for increasing hIK current). At least 1000 times more potent than 1-EBIO (ab120258). Can be used in conjunction with CyPPA (ab120829) to distinguish SK1 and SK3 subtypes.
Store at +4°C. The product can be stored for up to 12 months.
Soluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Hougaard C et al. Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br J Pharmacol151:655-65 (2007).
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Pandita RK et al. Urodynamic effects of intravesical administration of the new small/intermediate conductance calcium activated potassium channel activator NS309 in freely moving, conscious rats. J Urol176:1220-4 (2006).
Read more (PubMed: 16890729) »
Strøbaek D et al. Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime). Biochim Biophys Acta1665:1-5 (2004).
Read more (PubMed: 15471565) »