製品の概要

  • 製品名Anti-NRG4 antibody
    NRG4 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to NRG4
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    A mixture of 2 KLH conjugated synthetic peptides selected from center and C terminal region of human NRG4.

  • ポジティブ・コントロール
    • IHC-P: Human cancer tissue.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Protein G purified
  • 特記事項(精製)This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab60090 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
IHC-P 1/20 - 1/100.

ターゲット情報

  • 機能Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
  • 配列類似性Belongs to the neuregulin family.
    Contains 1 EGF-like domain.
  • ドメインThe cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization.
    ERBB receptor binding is elicited entirely by the EGF-like domain.
  • 翻訳後修飾Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
    Extensive glycosylation precedes the proteolytic cleavage.
  • 細胞内局在Secreted and Cell membrane. Does not seem to be active.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DKFZp779N0541 antibody
    • DKFZp779N1944 antibody
    • Heregulin 4 antibody
    • HRG4 antibody
    • Neuregulin 4 antibody
    • Neuregulin-4 antibody
    • NRG-4 antibody
    • NRG4 antibody
    • NRG4_HUMAN antibody
    • pro-neuregulin-4, membrane-bound isoform antibody
    • Pro-NRG4 antibody
    see all

Anti-NRG4 antibody 画像

  • Ab60090 (1/20 dilutio) staining NRG4 in formalin fixed, paraffin embedded human cancer tissue sections by immunohistochemistry. ab60090 was peroxidase conjugated to the secondary antibody, followed by AEC staining.
    BC = breast carcinoma.

Anti-NRG4 antibody (ab60090) 使用論文

ab60090 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"