製品の概要

  • 製品名Anti-NRAS antibody
    NRAS 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to NRAS
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Guinea pig, Dog, Pig, Opossum, Orangutan
  • 免疫原

    Synthetic peptide:

    C-RMKKLNSSDDGTQ

    , corresponding to internal sequence amino acids 167-179 of Human NRAS (NP_002515.1).

  • ポジティブ・コントロール
    • Human Small Intestine tissue and A431 lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab118814 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.01 - 0.03 µg/ml. Predicted molecular weight: 21 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
  • 関連疾患Defects in NRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia.
    Defects in NRAS are the cause of Noonan syndrome type 6 (NS6) [MIM:613224]. A syndrome characterized by facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears. Other features can include short stature, a short neck with webbing or redundancy of skin, cardiac anomalies, deafness, motor delay and variable intellectual deficits.
  • 配列類似性Belongs to the small GTPase superfamily. Ras family.
  • 翻訳後修飾Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
  • 細胞内局在Cell membrane. Golgi apparatus membrane. Shuttles between the plasma membrane and the Golgi apparatus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ALPS4 antibody
    • AV095280 antibody
    • GTPase NRas antibody
    • HRAS1 antibody
    • N ras antibody
    • N ras protein part 4 antibody
    • Neuroblastoma RAS viral (v ras) oncogene homolog antibody
    • NRAS antibody
    • NRAS1 antibody
    • NS6 antibody
    • OTTHUMP00000013879 antibody
    • OTTMUSP00000023521 antibody
    • RASN_HUMAN antibody
    • Transforming protein N Ras antibody
    • Transforming protein N-Ras antibody
    • v ras neuroblastoma RAS viral oncogene homolog antibody
    see all

Anti-NRAS antibody 画像

  • ab118814, at 2.5 µg/ml, staining NRAS in formalin-fixed, paraffin-embedded Human Small Intestine tissue by Immunohistochemistry using a biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Anti-NRAS antibody (ab118814) at 0.01 µg/ml + A431 lysate in RIPA buffer at 35 µg

    Predicted band size : 21 kDa

Anti-NRAS antibody (ab118814) 使用論文

ab118814 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab118814.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"