製品の概要

  • 製品名Anti-NR2E3 antibody
    NR2E3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to NR2E3
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 169-198 of Human NR2E3 (NP_055064.1, NP_057430.1).

  • ポジティブ・コントロール
    • WiDr cell line lysates.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab123091 purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab123091 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 45 kDa.

ターゲット情報

  • 機能Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M-and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.
  • 組織特異性Eye specific; found solely in the outer nuclear layer of the adult neurosensory retina, where the nuclei of cone and rod photoreceptors reside.
  • 関連疾患Defects in NR2E3 are a cause of enhanced S cone syndrome (ESCS) [MIM:268100]. ESCS is an autosomal recessive retinopathy in which patients have increased sensitivity to blue light; perception of blue light is mediated by what is normally the least populous cone photoreceptor subtype, the S (short wavelength, blue) cones. ESCS is also associated with visual loss, with night blindness occurring from early in life, varying degrees of L (long, red)- and M (middle, green)-cone vision, and retinal degeneration.
    Defects in NR2E3 are the cause of retinitis pigmentosa type 37 (RP37) [MIM:611131]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP37 inheritance is autosomal dominant.
  • 配列類似性Belongs to the nuclear hormone receptor family. NR2 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 翻訳後修飾Di- and tri-sumoylated in developing retina. PIAS3-mediated sumoylation promotes repression of cone-specific gene expression and activation of rod-specific genes. Sumoylation on Lys-185 appears to be the main site.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ESCS antibody
    • MGC49976 antibody
    • NR2 E3 antibody
    • Nr2e3 antibody
    • NR2E3_HUMAN antibody
    • Nuclear receptor subfamily 2 group E member 3 antibody
    • Photoreceptor specific nuclear receptor antibody
    • Photoreceptor-specific nuclear receptor antibody
    • PNR antibody
    • Rd 7 antibody
    • Rd7 antibody
    • Retina specific nuclear receptor antibody
    • Retina-specific nuclear receptor antibody
    • Retinal degeneration 7 antibody
    • RNR antibody
    • RP37 antibody
    see all

Anti-NR2E3 antibody 画像

  • Anti-NR2E3 antibody (ab123091) at 1/100 dilution + WiDr cell line lysates at 35 µg

    Predicted band size : 45 kDa

Anti-NR2E3 antibody (ab123091) 使用論文

ab123091 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab123091.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"